ENSMUSG00000028789


Mus musculus

Features
Gene ID: ENSMUSG00000028789
  
Biological name :Azin2
  
Synonyms : Antizyme inhibitor 2 / Azin2 / Q8BVM4
  
Possible biological names infered from orthology : Q96A70
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 128930233
Gene end: 128962442
  
Corresponding Affymetrix probe sets: 10516529 (MoGene1.0st)   1439649_at (Mouse Genome 430 2.0 Array)   1442093_at (Mouse Genome 430 2.0 Array)   1444585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114086
Ensembl peptide - ENSMUSP00000122240
Ensembl peptide - ENSMUSP00000030581
Ensembl peptide - ENSMUSP00000101683
NCBI entrez gene - 242669     See in Manteia.
MGI - MGI:2442093
RefSeq - XM_011240538
RefSeq - NM_001301841
RefSeq - NM_172875
RefSeq - XM_006503106
RefSeq - XM_006503107
RefSeq - XM_006503108
RefSeq Peptide - NP_766463
RefSeq Peptide - NP_001288770
swissprot - B2RSR5
swissprot - A8Y5E7
swissprot - Q8BVM4
swissprot - A2A821
Ensembl - ENSMUSG00000028789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AZIN2ENSGALG00000003614Gallus gallus
 AZIN2ENSG00000142920Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Odc1 / P00860 / ornithine decarboxylase, structural 1 / P11926* / ornithine decarboxylase 1*ENSMUSG0000001117948
Azin1 / O35484 / Antizyme inhibitor 1 / O14977*ENSMUSG0000003745842
Gm853ENSMUSG0000002312041


Protein motifs (from Interpro)
Interpro ID Name
 IPR000183  Ornithine/DAP/Arg decarboxylase
 IPR002433  Ornithine decarboxylase
 IPR009006  Alanine racemase/group IV decarboxylase, C-terminal
 IPR022643  Orn/DAP/Arg decarboxylase 2, C-terminal
 IPR022644  Orn/DAP/Arg decarboxylase 2, N-terminal
 IPR022657  Orn/DAP/Arg decarboxylase 2, conserved site
 IPR029066  PLP-binding barrel
 IPR031173  Antizyme inhibitor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006591 ornithine metabolic process IDA
 biological_processGO:0006596 polyamine biosynthetic process IEA
 biological_processGO:0015847 putrescine transport IDA
 biological_processGO:0033387 putrescine biosynthetic process from ornithine IBA
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0098629 trans-Golgi network membrane organization ISO
 biological_processGO:1902269 positive regulation of polyamine transmembrane transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005801 cis-Golgi network IDA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle ISS
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:1990005 granular vesicle ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015489 putrescine transmembrane transporter activity IDA
 molecular_functionGO:0042978 ornithine decarboxylase activator activity IEA


Pathways (from Reactome)
Pathway description
Agmatine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Stat5atm2Mam Stat5btm1Mam/Del(11Stat5a-Stat5b)1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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