ENSG00000182240


Homo sapiens

Features
Gene ID: ENSG00000182240
  
Biological name :BACE2
  
Synonyms : BACE2 / beta-site APP-cleaving enzyme 2 / Q9Y5Z0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.2
Gene start: 41167801
Gene end: 41282518
  
Corresponding Affymetrix probe sets: 217867_x_at (Human Genome U133 Plus 2.0 Array)   222446_s_at (Human Genome U133 Plus 2.0 Array)   227051_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000327528
Ensembl peptide - ENSP00000332979
Ensembl peptide - ENSP00000333854
NCBI entrez gene - 25825     See in Manteia.
OMIM - 605668
RefSeq - XM_017028314
RefSeq - NM_012105
RefSeq - NM_138991
RefSeq - NM_138992
RefSeq Peptide - NP_620476
RefSeq Peptide - NP_620477
RefSeq Peptide - NP_036237
swissprot - Q9Y5Z0
Ensembl - ENSG00000182240
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bace2ENSDARG00000044781Danio rerio
 BACE2ENSGALG00000034932Gallus gallus
 Bace2ENSMUSG00000040605Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BACE1 / P56817 / beta-secretase 1ENSG0000018631845


Protein motifs (from Interpro)
Interpro ID Name
 IPR001461  Aspartic peptidase A1 family
 IPR001969  Aspartic peptidase, active site
 IPR009119  Beta-secretase BACE
 IPR009121  Beta-secretase BACE2
 IPR021109  Aspartic peptidase domain superfamily
 IPR033121  Peptidase family A1 domain
 IPR033874  Memapsin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis NAS
 biological_processGO:0006509 membrane protein ectodomain proteolysis IDA
 biological_processGO:0016486 peptide hormone processing NAS
 biological_processGO:0030163 protein catabolic process IBA
 biological_processGO:0042985 negative regulation of amyloid precursor protein biosynthetic process IMP
 biological_processGO:0050435 amyloid-beta metabolic process IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0001540 amyloid-beta binding IBA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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