ENSMUSG00000040605


Mus musculus

Features
Gene ID: ENSMUSG00000040605
  
Biological name :Bace2
  
Synonyms : Bace2 / beta-site APP-cleaving enzyme 2
  
Possible biological names infered from orthology : Q9Y5Z0
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C4
Gene start: 97356728
Gene end: 97439012
  
Corresponding Affymetrix probe sets: 10437210 (MoGene1.0st)   1416673_at (Mouse Genome 430 2.0 Array)   1435581_at (Mouse Genome 430 2.0 Array)   1437846_x_at (Mouse Genome 430 2.0 Array)   1438645_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043918
NCBI entrez gene - 56175     See in Manteia.
MGI - MGI:1860440
RefSeq - NM_019517
RefSeq - XM_006523068
RefSeq Peptide - NP_062390
swissprot - A0A0R4J0I8
Ensembl - ENSMUSG00000040605
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bace2ENSDARG00000044781Danio rerio
 BACE2ENSGALG00000034932Gallus gallus
 BACE2ENSG00000182240Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bace1 / P56818 / Beta-secretase 1 / P56817*ENSMUSG0000003208645


Protein motifs (from Interpro)
Interpro ID Name
 IPR001461  Aspartic peptidase A1 family
 IPR001969  Aspartic peptidase, active site
 IPR009119  Beta-secretase BACE
 IPR009121  Beta-secretase BACE2
 IPR021109  Aspartic peptidase domain superfamily
 IPR033121  Peptidase family A1 domain
 IPR033874  Memapsin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0042985 negative regulation of amyloid precursor protein biosynthetic process IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Bace1tm2Psa/Bace1tm2Psa
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Bace1tm1Psa/Bace1tm1Psa,Bace2tm1Bdes/Bace2tm1Bdes
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1)

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bace1tm1Psa/Bace1tm1Psa,Bace2tm1Bdes/Bace2tm1Bdes
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bace1tm2Psa/Bace1tm2Psa
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bace1tm1Psa/Bace1tm1Psa,Bace2tm1Bdes/Bace2tm1Bdes
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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