ENSG00000183960


Homo sapiens

Features
Gene ID: ENSG00000183960
  
Biological name :KCNH8
  
Synonyms : KCNH8 / potassium voltage-gated channel subfamily H member 8 / Q96L42
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p24.3
Gene start: 19148454
Gene end: 19535646
  
Corresponding Affymetrix probe sets: 1552742_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328813
Ensembl peptide - ENSP00000412141
NCBI entrez gene - 131096     See in Manteia.
OMIM - 608260
RefSeq - XM_017005702
RefSeq - NM_144633
RefSeq - XM_017005699
RefSeq - XM_017005700
RefSeq - XM_017005701
RefSeq - XM_011533347
RefSeq - XM_017005698
RefSeq Peptide - NP_653234
swissprot - Q96L42
swissprot - F8WCG6
Ensembl - ENSG00000183960
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnh8ENSDARG00000062640Danio rerio
 KCNH8ENSGALG00000011262Gallus gallus
 Kcnh8ENSMUSG00000035580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNH4 / Q9UQ05 / potassium voltage-gated channel subfamily H member 4ENSG0000008955853
KCNH3 / Q9ULD8 / potassium voltage-gated channel subfamily H member 3ENSG0000013551948
KCNH7 / Q9NS40 / potassium voltage-gated channel subfamily H member 7ENSG0000018461134
KCNH2 / Q12809 / potassium voltage-gated channel subfamily H member 2ENSG0000005511833
KCNH6 / Q9H252 / potassium voltage-gated channel subfamily H member 6ENSG0000017382632
KCNH1 / O95259 / potassium voltage-gated channel subfamily H member 1ENSG0000014347328
KCNH5 / Q8NCM2 / potassium voltage-gated channel subfamily H member 5ENSG0000014001527
AL590132.1ENSG0000028429917
AC092017.3ENSG000002839523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000700  PAS-associated, C-terminal
 IPR001610  PAC motif
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR003950  Potassium channel, voltage-dependent, ELK
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000160 phosphorelay signal transduction system IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000155 phosphorelay sensor kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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