ENSG00000140015


Homo sapiens

Features
Gene ID: ENSG00000140015
  
Biological name :KCNH5
  
Synonyms : KCNH5 / potassium voltage-gated channel subfamily H member 5 / Q8NCM2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q23.2
Gene start: 62699454
Gene end: 63102037
  
Corresponding Affymetrix probe sets: 1555074_a_at (Human Genome U133 Plus 2.0 Array)   1555304_a_at (Human Genome U133 Plus 2.0 Array)   242502_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000321427
Ensembl peptide - ENSP00000378419
Ensembl peptide - ENSP00000395439
NCBI entrez gene - 27133     See in Manteia.
OMIM - 605716
RefSeq - NM_139318
RefSeq - NM_172375
RefSeq Peptide - NP_647479
RefSeq Peptide - NP_758963
swissprot - Q8NCM2
Ensembl - ENSG00000140015
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnh5aENSDARG00000043220Danio rerio
 KCNH5ENSGALG00000011858Gallus gallus
 Kcnh5ENSMUSG00000034402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNH1 / O95259 / potassium voltage-gated channel subfamily H member 1ENSG0000014347373
AL590132.1ENSG0000028429938
KCNH2 / Q12809 / potassium voltage-gated channel subfamily H member 2ENSG0000005511833
KCNH7 / Q9NS40 / potassium voltage-gated channel subfamily H member 7ENSG0000018461132
KCNH8 / Q96L42 / potassium voltage-gated channel subfamily H member 8ENSG0000018396031
KCNH3 / Q9ULD8 / potassium voltage-gated channel subfamily H member 3ENSG0000013551931
KCNH6 / Q9H252 / potassium voltage-gated channel subfamily H member 6ENSG0000017382631
KCNH4 / Q9UQ05 / potassium voltage-gated channel subfamily H member 4ENSG0000008955831
AC092017.3ENSG000002839528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000700  PAS-associated, C-terminal
 IPR001610  PAC motif
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR003949  Potassium channel, voltage-dependent, EAG
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR030171  Potassium voltage-gated channel subfamily H member 5
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000160 phosphorelay signal transduction system IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IDA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000155 phosphorelay sensor kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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