ENSMUSG00000034402


Mus musculus

Features
Gene ID: ENSMUSG00000034402
  
Biological name :Kcnh5
  
Synonyms : Kcnh5 / Potassium voltage-gated channel subfamily H member 5 / Q920E3
  
Possible biological names infered from orthology : Q8NCM2
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 74897220
Gene end: 75177332
  
Corresponding Affymetrix probe sets: 10400989 (MoGene1.0st)   1441742_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046864
NCBI entrez gene - 238271     See in Manteia.
MGI - MGI:3584508
RefSeq - NM_172805
RefSeq Peptide - NP_766393
swissprot - Q920E3
Ensembl - ENSMUSG00000034402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnh5aENSDARG00000043220Danio rerio
 KCNH5ENSGALG00000011858Gallus gallus
 KCNH5ENSG00000140015Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnh1 / potassium voltage-gated channel subfamily H member 1 / O95259*ENSMUSG0000005824873
Kcnh2 / potassium voltage-gated channel subfamily H member 2 / Q12809*ENSMUSG0000003831933
Kcnh3 / Q9WVJ0 / Potassium voltage-gated channel subfamily H member 3 / Q9ULD8*ENSMUSG0000003757932
Kcnh7 / Q9ER47 / Potassium voltage-gated channel subfamily H member 7 / Q9NS40*ENSMUSG0000005974232
Kcnh6 / potassium voltage-gated channel, subfamily H (eag-related), member 6 / Q9H252* / potassium voltage-gated channel subfamily H member 6*ENSMUSG0000000190131
Kcnh8 / potassium voltage-gated channel subfamily H member 8 / Q96L42*ENSMUSG0000003558031
Kcnh4 / potassium voltage-gated channel subfamily H member 4 / Q9UQ05*ENSMUSG0000003535531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000700  PAS-associated, C-terminal
 IPR001610  PAC motif
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR003949  Potassium channel, voltage-dependent, EAG
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR030171  Potassium voltage-gated channel subfamily H member 5
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000160 phosphorelay signal transduction system IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000155 phosphorelay sensor kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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