ENSMUSG00000058248


Mus musculus

Features
Gene ID: ENSMUSG00000058248
  
Biological name :Kcnh1
  
Synonyms : Kcnh1 / potassium voltage-gated channel subfamily H member 1
  
Possible biological names infered from orthology : O95259
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H6
Gene start: 192190774
Gene end: 192510159
  
Corresponding Affymetrix probe sets: 10352798 (MoGene1.0st)   1418414_at (Mouse Genome 430 2.0 Array)   1435994_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106468
Ensembl peptide - ENSMUSP00000141247
Ensembl peptide - ENSMUSP00000077563
NCBI entrez gene - 16510     See in Manteia.
MGI - MGI:1341721
RefSeq - NM_010600
RefSeq - XM_006497229
RefSeq - NM_001038607
RefSeq Peptide - NP_001033696
RefSeq Peptide - NP_034730
swissprot - A0A0A6YVS8
swissprot - Q3UHC9
swissprot - A0A1L1M1J8
Ensembl - ENSMUSG00000058248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnh1aENSDARG00000024167Danio rerio
 kcnh1aENSDARG00000023236Danio rerio
 ENSGALG00000009877Gallus gallus
 KCNH1ENSG00000143473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnh5 / Q920E3 / Potassium voltage-gated channel subfamily H member 5 / Q8NCM2*ENSMUSG0000003440273
Kcnh4 / potassium voltage-gated channel subfamily H member 4 / Q9UQ05*ENSMUSG0000003535532
Kcnh6 / potassium voltage-gated channel, subfamily H (eag-related), member 6 / Q9H252* / potassium voltage-gated channel subfamily H member 6*ENSMUSG0000000190132
Kcnh2 / potassium voltage-gated channel subfamily H member 2 / Q12809*ENSMUSG0000003831932
Kcnh8 / potassium voltage-gated channel subfamily H member 8 / Q96L42*ENSMUSG0000003558032
Kcnh7 / Q9ER47 / Potassium voltage-gated channel subfamily H member 7 / Q9NS40*ENSMUSG0000005974232
Kcnh3 / Q9WVJ0 / Potassium voltage-gated channel subfamily H member 3 / Q9ULD8*ENSMUSG0000003757931


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000700  PAS-associated, C-terminal
 IPR001610  PAC motif
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR003949  Potassium channel, voltage-dependent, EAG
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR030170  Potassium voltage-gated channel subfamily H member 1
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000160 phosphorelay signal transduction system IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0034705 potassium channel complex IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000155 phosphorelay sensor kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005251 delayed rectifier potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA
 molecular_functionGO:1902936 phosphatidylinositol bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0003360 depression-related behavior 
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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