ENSMUSG00000037579


Mus musculus

Features
Gene ID: ENSMUSG00000037579
  
Biological name :Kcnh3
  
Synonyms : Kcnh3 / Potassium voltage-gated channel subfamily H member 3 / Q9WVJ0
  
Possible biological names infered from orthology : Q9ULD8
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 99224861
Gene end: 99242817
  
Corresponding Affymetrix probe sets: 10426704 (MoGene1.0st)   1421619_at (Mouse Genome 430 2.0 Array)   1431690_at (Mouse Genome 430 2.0 Array)   1445805_x_at (Mouse Genome 430 2.0 Array)   1459107_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040548
NCBI entrez gene - 16512     See in Manteia.
MGI - MGI:1341723
RefSeq - XM_006520484
RefSeq - NM_010601
RefSeq - XM_006520483
RefSeq Peptide - NP_034731
swissprot - Q9WVJ0
Ensembl - ENSMUSG00000037579
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnh3ENSDARG00000069560Danio rerio
 KCNH3ENSG00000135519Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnh8 / potassium voltage-gated channel subfamily H member 8 / Q96L42*ENSMUSG0000003558049
Kcnh4 / potassium voltage-gated channel subfamily H member 4 / Q9UQ05*ENSMUSG0000003535547
Kcnh2 / potassium voltage-gated channel subfamily H member 2 / Q12809*ENSMUSG0000003831931
Kcnh7 / Q9ER47 / Potassium voltage-gated channel subfamily H member 7 / Q9NS40*ENSMUSG0000005974230
Kcnh6 / potassium voltage-gated channel, subfamily H (eag-related), member 6 / Q9H252* / potassium voltage-gated channel subfamily H member 6*ENSMUSG0000000190129
Kcnh1 / potassium voltage-gated channel subfamily H member 1 / O95259*ENSMUSG0000005824828
Kcnh5 / Q920E3 / Potassium voltage-gated channel subfamily H member 5 / Q8NCM2*ENSMUSG0000003440228


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000700  PAS-associated, C-terminal
 IPR001610  PAC motif
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR003950  Potassium channel, voltage-dependent, ELK
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000160 phosphorelay signal transduction system IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000155 phosphorelay sensor kinase activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000948 nonconvulsive seizures "seizures without uncontrolled motor activity, but with impairment of consciousness" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Rps/Ptentm1Rps,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Rps/Ptentm1Rps,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Rps/Ptentm1Rps,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

Allelic Composition: Kcnh3tm1Akmi/Kcnh3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Kcnh3tm1.2Tije/Kcnh3tm1.2Tije
Genetic Background: involves: C57BL/6

 MP:0003466 decreased single cell response threshold "reduction in the value at which a stimulus first elicits a recordable response" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Kcnh3tm1.2Tije/Kcnh3tm1.2Tije
Genetic Background: involves: C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

Allelic Composition: Kcnh3tm1.1(KOMP)Vlcg/Kcnh3+
Genetic Background: C57BL/6N-Kcnh3tm1.1(KOMP)Vlcg/J

 MP:0005385 cardiovascular system phenotype 
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Rps/Ptentm1Rps,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

Allelic Composition: Kcnh3tm1Akmi/Kcnh3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Rps/Ptentm1Rps,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
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Allelic Composition: Kcnh3tm1.2Tije/Kcnh3tm1.2Tije
Genetic Background: involves: C57BL/6

Allelic Composition: Kcnh3tm1.2Tije/Kcnh3+
Genetic Background: involves: C57BL/6

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Kcnh3tm1.1(KOMP)Vlcg/Kcnh3+
Genetic Background: C57BL/6N-Kcnh3tm1.1(KOMP)Vlcg/J

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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