Manteia

ENSMUSG00000035355

Mus musculus

Features

Gene ID:	ENSMUSG00000035355

Biological name :	Kcnh4

Synonyms :	Kcnh4 / potassium voltage-gated channel subfamily H member 4

Possible biological names infered from orthology :	Q9UQ05

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	D
Gene start:	100740376
Gene end:	100759942

Corresponding Affymetrix probe sets:	10391254 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000102986 Ensembl peptide - ENSMUSP00000102984 NCBI entrez gene - 380728 See in Manteia. MGI - MGI:2156184 RefSeq - NM_001081194 RefSeq - XM_006533646 RefSeq Peptide - NP_001074663 swissprot - A2A5F7 Ensembl - ENSMUSG00000035355

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnh8 / potassium voltage-gated channel subfamily H member 8 / Q96L42*	ENSMUSG00000035580	57
Kcnh3 / Q9WVJ0 / Potassium voltage-gated channel subfamily H member 3 / Q9ULD8*	ENSMUSG00000037579	50
Kcnh2 / potassium voltage-gated channel subfamily H member 2 / Q12809*	ENSMUSG00000038319	36
Kcnh7 / Q9ER47 / Potassium voltage-gated channel subfamily H member 7 / Q9NS40*	ENSMUSG00000059742	34
Kcnh6 / potassium voltage-gated channel, subfamily H (eag-related), member 6 / Q9H252* / potassium voltage-gated channel subfamily H member 6*	ENSMUSG00000001901	34
Kcnh1 / potassium voltage-gated channel subfamily H member 1 / O95259*	ENSMUSG00000058248	31
Kcnh5 / Q920E3 / Potassium voltage-gated channel subfamily H member 5 / Q8NCM2*	ENSMUSG00000034402	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR000014	PAS domain
IPR000595	Cyclic nucleotide-binding domain
IPR000700	PAS-associated, C-terminal
IPR001610	PAC motif
IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR003950	Potassium channel, voltage-dependent, ELK
IPR005821	Ion transport domain
IPR014710	RmlC-like jelly roll fold
IPR018490	Cyclic nucleotide-binding-like
IPR035965	PAS domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000160	phosphorelay signal transduction system	IEA
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006813	potassium ion transport	IEA
biological_process	GO:0023014	signal transduction by protein phosphorylation	IEA
biological_process	GO:0034765	regulation of ion transmembrane transport	IEA
biological_process	GO:0042391	regulation of membrane potential	IBA
biological_process	GO:0055085	transmembrane transport	IEA
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0000155	phosphorelay sensor kinase activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005244	voltage-gated ion channel activity	IEA
molecular_function	GO:0005249	voltage-gated potassium channel activity	IBA
molecular_function	GO:0005267	potassium channel activity	IEA

Pathways (from Reactome)

Pathway description

Voltage gated Potassium channels

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺ Genetic Background: C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺ Genetic Background: C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺ Genetic Background: C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics
MP:0008347	decreased gamma-delta T cell number	"reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺ Genetic Background: C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr