ENSG00000185745


Homo sapiens

Features
Gene ID: ENSG00000185745
  
Biological name :IFIT1
  
Synonyms : IFIT1 / interferon induced protein with tetratricopeptide repeats 1 / P09914
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q23.31
Gene start: 89392546
Gene end: 89406486
  
Corresponding Affymetrix probe sets: 203153_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360869
Ensembl peptide - ENSP00000441968
NCBI entrez gene - 3434     See in Manteia.
OMIM - 147690
RefSeq - NM_001548
RefSeq - NM_001270930
RefSeq - NM_001270927
RefSeq - NM_001270928
RefSeq - NM_001270929
RefSeq Peptide - NP_001257856
RefSeq Peptide - NP_001257857
RefSeq Peptide - NP_001257858
RefSeq Peptide - NP_001257859
RefSeq Peptide - NP_001539
swissprot - P09914
Ensembl - ENSG00000185745
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR759879.1ENSDARG00000088069Danio rerio
 ifit10ENSDARG00000007467Danio rerio
 ifit11ENSDARG00000090537Danio rerio
 ifit12ENSDARG00000090977Danio rerio
 ifit14ENSDARG00000071012Danio rerio
 ifit15ENSDARG00000043584Danio rerio
 ifit16ENSDARG00000056976Danio rerio
 ifit8ENSDARG00000057173Danio rerio
 IFIT5ENSGALG00000045085Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFIT1B / Q5T764 / interferon induced protein with tetratricopeptide repeats 1BENSG0000020401067
IFIT5 / Q13325 / interferon induced protein with tetratricopeptide repeats 5ENSG0000015277855
IFIT2 / P09913 / interferon induced protein with tetratricopeptide repeats 2ENSG0000011992245
IFIT3 / O14879 / interferon induced protein with tetratricopeptide repeats 3ENSG0000011991742


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR024121  Interferon-induced protein with tetratricopeptide repeats 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019060 intracellular transport of viral protein in host cell IDA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0045070 positive regulation of viral genome replication IDA
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050688 regulation of defense response to virus IEA
 biological_processGO:0050689 negative regulation of defense response to virus by host IDA
 biological_processGO:0051097 negative regulation of helicase activity IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0071357 cellular response to type I interferon IDA
 biological_processGO:0071360 cellular response to exogenous dsRNA IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043657 host cell IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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