ENSG00000186871


Homo sapiens

Features
Gene ID: ENSG00000186871
  
Biological name :ERCC6L
  
Synonyms : ERCC6L / ERCC excision repair 6 like, spindle assembly checkpoint helicase / Q2NKX8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q13.1
Gene start: 72204657
Gene end: 72239047
  
Corresponding Affymetrix probe sets: 219650_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362761
Ensembl peptide - ENSP00000334675
NCBI entrez gene - 54821     See in Manteia.
OMIM - 300687
RefSeq - NM_001009954
RefSeq - NM_017669
RefSeq Peptide - NP_001009954
RefSeq Peptide - NP_060139
swissprot - Q2NKX8
swissprot - B5MDQ0
Ensembl - ENSG00000186871
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2BGR3ENSDARG00000002479Danio rerio
 ERCC6LENSGALG00000003881Gallus gallus
 Ercc6lENSMUSG00000051220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERCC6 / P0DP91 / Q03468 / Q8N328 / ERCC excision repair 6, chromatin remodeling factorENSG0000022583023
Q5T890 / ERCC6L2 / ERCC excision repair 6 like 2ENSG0000018215015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015616 DNA translocase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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