ENSG00000197959


Homo sapiens

Features
Gene ID: ENSG00000197959
  
Biological name :DNM3
  
Synonyms : DNM3 / dynamin 3 / Q9UQ16
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q24.3
Gene start: 171841498
Gene end: 172418466
  
Corresponding Affymetrix probe sets: 1558501_at (Human Genome U133 Plus 2.0 Array)   1558502_s_at (Human Genome U133 Plus 2.0 Array)   209839_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429416
Ensembl peptide - ENSP00000429165
Ensembl peptide - ENSP00000429701
Ensembl peptide - ENSP00000486701
Ensembl peptide - ENSP00000347457
Ensembl peptide - ENSP00000356705
Ensembl peptide - ENSP00000356707
NCBI entrez gene - 26052     See in Manteia.
OMIM - 611445
RefSeq - XM_017000992
RefSeq - XM_017000984
RefSeq - XM_017000985
RefSeq - XM_017000986
RefSeq - XM_017000987
RefSeq - XM_017000988
RefSeq - XM_017000989
RefSeq - XM_017000990
RefSeq - XM_017000991
RefSeq - NM_001136127
RefSeq - NM_001278252
RefSeq - NM_015569
RefSeq - XM_005245079
RefSeq - XM_005245080
RefSeq - XM_006711268
RefSeq - XM_017000976
RefSeq - XM_017000977
RefSeq - XM_017000978
RefSeq - XM_017000979
RefSeq - XM_017000980
RefSeq - XM_017000981
RefSeq - XM_017000982
RefSeq - XM_017000983
RefSeq Peptide - NP_056384
RefSeq Peptide - NP_001129599
RefSeq Peptide - NP_001265181
RefSeq Peptide - NP_001337133
swissprot - E5RHK8
swissprot - H0YBC6
swissprot - Q9UQ16
swissprot - E5RIK2
Ensembl - ENSG00000197959
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003164Gallus gallus
 ENSGALG00000033244Gallus gallus
 Dnm3ENSMUSG00000040265Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNM1 / Q05193 / dynamin 1ENSG0000010697680
DNM2 / P50570 / dynamin 2ENSG0000007980580
DNM1L / O00429 / dynamin 1 likeENSG0000008747034
MX1 / P20591 / MX dynamin like GTPase 1ENSG0000015760123
MX2 / P20592 / MX dynamin like GTPase 2ENSG0000018348621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000375  Dynamin central domain
 IPR001401  Dynamin, GTPase domain
 IPR001849  Pleckstrin homology domain
 IPR003130  Dynamin GTPase effector
 IPR011993  PH-like domain superfamily
 IPR019762  Dynamin, GTPase region, conserved site
 IPR020850  GTPase effector domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IBA
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
 biological_processGO:0006897 endocytosis ISS
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane IEA
 biological_processGO:0046847 filopodium assembly ISS
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061025 membrane fusion IBA
 biological_processGO:0098884 postsynaptic neurotransmitter receptor internalization IEA
 biological_processGO:1903423 positive regulation of synaptic vesicle recycling IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 cellular_componentGO:0043083 synaptic cleft IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0044327 dendritic spine head IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0061828 apical tubulobulbar complex IEA
 cellular_componentGO:0061829 basal tubulobulbar complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098844 postsynaptic endocytic zone membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031798 type 1 metabotropic glutamate receptor binding IEA
 molecular_functionGO:0031802 type 5 metabotropic glutamate receptor binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Retrograde neurotrophin signalling
MHC class II antigen presentation
Recycling pathway of L1
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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