ENSG00000183486


Homo sapiens

Features
Gene ID: ENSG00000183486
  
Biological name :MX2
  
Synonyms : MX2 / MX dynamin like GTPase 2 / P20592
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.3
Gene start: 41361943
Gene end: 41409390
  
Corresponding Affymetrix probe sets: 204994_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000333657
Ensembl peptide - ENSP00000411179
Ensembl peptide - ENSP00000410188
Ensembl peptide - ENSP00000393975
Ensembl peptide - ENSP00000389256
NCBI entrez gene - 4600     See in Manteia.
OMIM - 147890
RefSeq - XM_005260983
RefSeq - XM_011529571
RefSeq - XM_011529572
RefSeq - XM_011529573
RefSeq - XM_011529574
RefSeq - XM_005260984
RefSeq - NM_002463
RefSeq Peptide - NP_002454
swissprot - P20592
swissprot - C9JS04
swissprot - C9JEL4
swissprot - C9J9T4
swissprot - C9JZQ9
Ensembl - ENSG00000183486
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxcENSDARG00000024789Danio rerio
 mxeENSDARG00000014427Danio rerio
 MX1ENSGALG00000016142Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MX1 / P20591 / MX dynamin like GTPase 1ENSG0000015760156
DNM3 / Q9UQ16 / dynamin 3ENSG0000019795926
DNM1 / Q05193 / dynamin 1ENSG0000010697625
DNM2 / P50570 / dynamin 2ENSG0000007980525
DNM1L / O00429 / dynamin 1 likeENSG0000008747024


Protein motifs (from Interpro)
Interpro ID Name
 IPR000375  Dynamin central domain
 IPR001401  Dynamin, GTPase domain
 IPR003130  Dynamin GTPase effector
 IPR019762  Dynamin, GTPase region, conserved site
 IPR020850  GTPase effector domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035455 response to interferon-alpha IDA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0061025 membrane fusion IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031966 mitochondrial membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IMP
 molecular_functionGO:0008017 microtubule binding IBA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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