ENSG00000157601


Homo sapiens

Features
Gene ID: ENSG00000157601
  
Biological name :MX1
  
Synonyms : MX1 / MX dynamin like GTPase 1 / P20591
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.3
Gene start: 41420304
Gene end: 41459214
  
Corresponding Affymetrix probe sets: 202086_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478441
Ensembl peptide - ENSP00000410523
Ensembl peptide - ENSP00000410989
Ensembl peptide - ENSP00000288383
Ensembl peptide - ENSP00000381599
Ensembl peptide - ENSP00000381601
Ensembl peptide - ENSP00000392151
Ensembl peptide - ENSP00000393931
Ensembl peptide - ENSP00000400923
Ensembl peptide - ENSP00000402215
Ensembl peptide - ENSP00000408498
NCBI entrez gene - 4599     See in Manteia.
OMIM - 147150
RefSeq - XM_017028352
RefSeq - NM_001282920
RefSeq - NM_002462
RefSeq - XM_005260978
RefSeq - XM_005260979
RefSeq - XM_005260980
RefSeq - XM_005260981
RefSeq - XM_005260982
RefSeq - XM_011529568
RefSeq - XM_011529570
RefSeq - XM_017028349
RefSeq - XM_017028350
RefSeq - XM_017028351
RefSeq - NM_001144925
RefSeq - NM_001178046
RefSeq Peptide - NP_001171517
RefSeq Peptide - NP_001269849
RefSeq Peptide - NP_002453
RefSeq Peptide - NP_001138397
swissprot - H9KVD0
swissprot - H9KVD3
swissprot - F8W8T1
swissprot - H9KVC3
swissprot - P20591
swissprot - H9KVC4
swissprot - H9KVC7
swissprot - H9KVC9
Ensembl - ENSG00000157601
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxcENSDARG00000024789Danio rerio
 mxeENSDARG00000014427Danio rerio
 MX1ENSGALG00000016142Gallus gallus
 Mx1ENSMUSG00000000386Mus musculus
 Mx2ENSMUSG00000023341Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MX2 / P20592 / MX dynamin like GTPase 2ENSG0000018348660
DNM2 / P50570 / dynamin 2ENSG0000007980529
DNM3 / Q9UQ16 / dynamin 3ENSG0000019795929
DNM1 / Q05193 / dynamin 1ENSG0000010697629
DNM1L / O00429 / dynamin 1 likeENSG0000008747026


Protein motifs (from Interpro)
Interpro ID Name
 IPR000375  Dynamin central domain
 IPR001401  Dynamin, GTPase domain
 IPR003130  Dynamin GTPase effector
 IPR019762  Dynamin, GTPase region, conserved site
 IPR020850  GTPase effector domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006952 defense response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0034340 response to type I interferon TAS
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0051607 defense response to virus IBA
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0061025 membrane fusion IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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