ENSG00000198728


Homo sapiens

Features
Gene ID: ENSG00000198728
  
Biological name :LDB1
  
Synonyms : LDB1 / LIM domain binding 1 / Q86U70
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.32
Gene start: 102107560
Gene end: 102120453
  
Corresponding Affymetrix probe sets: 203451_at (Human Genome U133 Plus 2.0 Array)   35160_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354616
Ensembl peptide - ENSP00000392466
NCBI entrez gene - 8861     See in Manteia.
OMIM - 603451
RefSeq - XM_017016869
RefSeq - NM_001113407
RefSeq - NM_001321612
RefSeq - NM_003893
RefSeq - XM_017016867
RefSeq - XM_017016868
RefSeq Peptide - NP_001106878
RefSeq Peptide - NP_001308541
RefSeq Peptide - NP_003884
swissprot - Q86U70
Ensembl - ENSG00000198728
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldb1aENSDARG00000010137Danio rerio
 ldb1aENSDARG00000103158Danio rerio
 LDB1ENSGALG00000007641Gallus gallus
 Ldb1ENSMUSG00000025223Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LDB2 / O43679 / LIM domain binding 2ENSG0000016974467


Protein motifs (from Interpro)
Interpro ID Name
 IPR029005  LIM-domain binding protein/SEUSS
 IPR030167  LIM domain-binding protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IEA
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0006351 transcription, DNA-templated NAS
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0010669 epithelial structure maintenance IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IEA
 biological_processGO:0022607 cellular component assembly IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0043549 regulation of kinase activity IEA
 biological_processGO:0043973 histone H3-K4 acetylation IEA
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046985 positive regulation of hemoglobin biosynthetic process IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IEA
 biological_processGO:0060322 head development IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:1990907 beta-catenin-TCF complex IDA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030274 LIM domain binding ISS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043621 protein self-association IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121454 LHX4 / Q969G2 / LIM homeobox 4  / complex
 ENSG00000016082 ISL1 / P61371 / ISL LIM homeobox 1  / complex
 ENSG00000198728 LDB1 / Q86U70 / LIM domain binding 1  / complex
 ENSG00000107187 LHX3 / Q9UBR4 / LIM homeobox 3  / complex






 

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