ENSMUSG00000025223


Mus musculus

Features
Gene ID: ENSMUSG00000025223
  
Biological name :Ldb1
  
Synonyms : Ldb1 / LIM domain-binding protein 1 / P70662
  
Possible biological names infered from orthology : LIM domain binding 1 / Q86U70
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 46032593
Gene end: 46045214
  
Corresponding Affymetrix probe sets: 10468159 (MoGene1.0st)   1452024_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053680
Ensembl peptide - ENSMUSP00000118546
Ensembl peptide - ENSMUSP00000026252
Ensembl peptide - ENSMUSP00000139562
Ensembl peptide - ENSMUSP00000114667
Ensembl peptide - ENSMUSP00000116909
NCBI entrez gene - 16825     See in Manteia.
MGI - MGI:894762
RefSeq - XM_011247157
RefSeq - XM_006526723
RefSeq - NM_010697
RefSeq - NM_001113408
RefSeq Peptide - NP_034827
RefSeq Peptide - NP_001106879
swissprot - P70662
swissprot - D3Z1C5
Ensembl - ENSMUSG00000025223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldb1aENSDARG00000010137Danio rerio
 ldb1aENSDARG00000103158Danio rerio
 LDB1ENSGALG00000007641Gallus gallus
 LDB1ENSG00000198728Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ldb2 / O55203 / Mus musculus LIM domain binding 2 (Ldb2), transcript variant 5, mRNA. / O43679* / LIM domain binding 2*ENSMUSG0000003970667


Protein motifs (from Interpro)
Interpro ID Name
 IPR029005  LIM-domain binding protein/SEUSS
 IPR030167  LIM domain-binding protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0001942 hair follicle development IGI
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009948 anterior/posterior axis specification IMP
 biological_processGO:0010669 epithelial structure maintenance IGI
 biological_processGO:0016055 Wnt signaling pathway IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IMP
 biological_processGO:0022607 cellular component assembly IGI
 biological_processGO:0030182 neuron differentiation IEP
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IMP
 biological_processGO:0035019 somatic stem cell population maintenance IGI
 biological_processGO:0043549 regulation of kinase activity IDA
 biological_processGO:0043973 histone H3-K4 acetylation IMP
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IMP
 biological_processGO:0045785 positive regulation of cell adhesion IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046985 positive regulation of hemoglobin biosynthetic process IMP
 biological_processGO:0051893 regulation of focal adhesion assembly IDA
 biological_processGO:0060319 primitive erythrocyte differentiation TAS
 biological_processGO:0060322 head development IGI
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0032991 protein-containing complex IPI
 cellular_componentGO:1990907 beta-catenin-TCF complex IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IPI
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030274 LIM domain binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043621 protein self-association IPI


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Vdrtm1Mbd/Vdr+
Genetic Background: involves: 129S4/SvJae

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lhx1tm1Bhr/Lhx1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Lhx1tm1Tmj/Lhx1tm2.1Bhr,Lhx5tm1Lmgd/Lhx5tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Lhx1tm1Tmj/Lhx1tm2.1Bhr,Lhx5tm1Lmgd/Lhx5tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Lhx1tm1Tmj/Lhx1tm2.1Bhr,Lhx5tm1Lmgd/Lhx5tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ldb1tm1.1Gsv/Ldb1tm1.1Gsv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb1tm1Lmgd/Ldb1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: C3H/He * C57BL/6

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb1tm1Lmgd/Ldb1+,Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic Background: involves: C3H/He * C57BL/6

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb1tm1.1Gsv/Ldb1tm1.1Gsv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004713 split notochord "the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008391 abnormal primordial germ cell morphology "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011455 absent glomerular endothelium fenestra "absence of the large plasma membrane-lined circular pores that normally perforate the flattened glomerular endothelium; loss of fenestrae may lead to a reduction in the glomerular filtration rate or proteinuria" [MGI:anna]
Show

Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011483 renal glomerular synechia "presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna]
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Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0012133 absent midbrain-hindbrain boundary "absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
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Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0012181 increased somite number "increase in the average number of somites formed relative to littermates or other controls" [MGI:anna]
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Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0012792 abnormal rhombomere 3 morphology "any structural anomaly of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005507]
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Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0012800 abnormal rhombomere 5 morphology "any structural anomaly of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005515]
Show

Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026468 Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*  / complex
 ENSMUSG00000025223 Ldb1 / P70662 / LIM domain-binding protein 1 / Q86U70* / LIM domain binding 1*  / complex
 ENSMUSG00000026934 Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*  / complex
 ENSMUSG00000042258 Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*  / complex






 

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