ENSMUSG00000026468


Mus musculus

Features
Gene ID: ENSMUSG00000026468
  
Biological name :Lhx4
  
Synonyms : Lhx4 / LIM/homeobox protein Lhx4 / P53776
  
Possible biological names infered from orthology : LIM homeobox 4 / Q969G2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 155698031
Gene end: 155751684
  
Corresponding Affymetrix probe sets: 10359027 (MoGene1.0st)   1421483_at (Mouse Genome 430 2.0 Array)   1439905_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141662
Ensembl peptide - ENSMUSP00000027740
NCBI entrez gene - 16872     See in Manteia.
MGI - MGI:101776
RefSeq - NM_010712
RefSeq - XM_006529169
RefSeq Peptide - NP_034842
swissprot - A0A0A6YWR5
swissprot - P53776
Ensembl - ENSMUSG00000026468
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhx4ENSDARG00000039458Danio rerio
 LHX4ENSGALG00000036587Gallus gallus
 LHX4ENSG00000121454Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*ENSMUSG0000002693464
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869838
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959536
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876529
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668628
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*ENSMUSG0000003231825
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225824
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*ENSMUSG0000002689023
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024723
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*ENSMUSG0000009622523
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*ENSMUSG0000001923022
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*ENSMUSG0000002826615
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611115
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022614
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*ENSMUSG0000003269811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008045 motor neuron axon guidance IGI
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0021526 medial motor column neuron differentiation IGI
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001070 abnormal abducens nerve morphology "any anomaly, deformity, or malformation of the 6th cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002329 abnormal blood gas "anomaly in the amount of oxygen and carbon dioxide in the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003972 decreased pituitary hormone level "less than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0008320 absent adenohypophysis "absence of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008336 absent gonadotrophs "absence of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010890 decreased alveolar lamellar body number "reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0013349 small Rathke s pouch "reduced size of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0013351 abnormal Rathke s pouch development "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

 MP:0013352 abnormal Rathke s pouch apoptosis "any change in the timing or number of Rathke s pouch cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp,Prop1df/Prop1df
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026468 Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*  / complex
 ENSMUSG00000025223 Ldb1 / P70662 / LIM domain-binding protein 1 / Q86U70* / LIM domain binding 1*  / complex
 ENSMUSG00000042258 Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr