ENSMUSG00000026890


Mus musculus

Features
Gene ID: ENSMUSG00000026890
  
Biological name :Lhx6
  
Synonyms : Lhx6 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9R1R0
  
Possible biological names infered from orthology : LIM homeobox 6 / Q9UPM6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 36081953
Gene end: 36105408
  
Corresponding Affymetrix probe sets: 10482095 (MoGene1.0st)   1422262_a_at (Mouse Genome 430 2.0 Array)   1425094_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135776
Ensembl peptide - ENSMUSP00000108591
Ensembl peptide - ENSMUSP00000135693
Ensembl peptide - ENSMUSP00000108584
Ensembl peptide - ENSMUSP00000108585
Ensembl peptide - ENSMUSP00000108587
Ensembl peptide - ENSMUSP00000108590
NCBI entrez gene - 16874     See in Manteia.
MGI - MGI:1306803
RefSeq - XM_017315869
RefSeq - NM_001083125
RefSeq - NM_001083126
RefSeq - NM_001083127
RefSeq - NM_001355125
RefSeq - NM_008500
RefSeq - XM_006497744
RefSeq Peptide - NP_001076596
RefSeq Peptide - NP_001342054
RefSeq Peptide - NP_032526
RefSeq Peptide - NP_001076594
RefSeq Peptide - NP_001076595
swissprot - Q9R1R0
swissprot - H9H9T0
swissprot - H3BLG4
swissprot - E9QN32
Ensembl - ENSMUSG00000026890
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhx6ENSDARG00000006896Danio rerio
 si:ch211-236k19.2ENSDARG00000052165Danio rerio
 LHX6ENSGALG00000001347Gallus gallus
 LHX6ENSG00000106852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*ENSMUSG0000009622551
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*ENSMUSG0000001923029
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024728
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*ENSMUSG0000002693425
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959524
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*ENSMUSG0000003231824
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225824
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876524
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869824
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668623
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*ENSMUSG0000002646823
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*ENSMUSG0000002826615
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611114
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022613
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*ENSMUSG0000003269811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021800 cerebral cortex tangential migration IMP
 biological_processGO:0021853 cerebral cortex GABAergic interneuron migration IMP
 biological_processGO:0021877 forebrain neuron fate commitment IGI
 biological_processGO:0021884 forebrain neuron development IGI
 biological_processGO:0021895 cerebral cortex neuron differentiation IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048469 cell maturation IMP
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(Tek-Procr)1Cte/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(Tek-Procr)1Cte/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(Tek-Procr)1Cte/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lhx6tm1Vpa/Lhx6tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Lhx6tm1Vpa/Lhx6tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lhx6tm1Vpa/Lhx6tm1Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(Tek-Procr)1Cte/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lhx6tm2Vpa/Lhx6tm2Vpa,Tg(Nkx2-1-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(Tek-Procr)1Cte/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
Show

Allelic Composition: Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx6tm1Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(Tek-Procr)1Cte/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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