ENSMUSG00000028266


Mus musculus

Features
Gene ID: ENSMUSG00000028266
  
Biological name :Lmo4
  
Synonyms : LIM domain transcription factor LMO4 / Lmo4 / P61969
  
Possible biological names infered from orthology : LIM domain only 4 / P61968
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H2
Gene start: 144188530
Gene end: 144205220
  
Corresponding Affymetrix probe sets: 10502510 (MoGene1.0st)   1420981_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142551
Ensembl peptide - ENSMUSP00000143035
Ensembl peptide - ENSMUSP00000113513
Ensembl peptide - ENSMUSP00000113840
Ensembl peptide - ENSMUSP00000113865
NCBI entrez gene - 16911     See in Manteia.
MGI - MGI:109360
RefSeq - NM_001161769
RefSeq - NM_001161770
RefSeq - NM_010723
RefSeq Peptide - NP_001155242
RefSeq Peptide - NP_034853
RefSeq Peptide - NP_001155241
swissprot - Q542S1
swissprot - A0A0G2JDX9
swissprot - P61969
swissprot - A0A0G2JF61
Ensembl - ENSMUSG00000028266
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmo4bENSDARG00000054749Danio rerio
 LMO4ENSGALG00000006252Gallus gallus
 LMO4ENSG00000143013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611142
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022641
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876538
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*ENSMUSG0000001923038
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*ENSMUSG0000003231838
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024737
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668637
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*ENSMUSG0000003269836
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*ENSMUSG0000002693436
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*ENSMUSG0000002689036
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*ENSMUSG0000009622535
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*ENSMUSG0000002646835
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869834
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225834
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959534


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IDA
 biological_processGO:0021522 spinal cord motor neuron differentiation IDA
 biological_processGO:0021527 spinal cord association neuron differentiation IGI
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0031333 negative regulation of protein complex assembly IDA
 biological_processGO:0033674 positive regulation of kinase activity IDA
 biological_processGO:0042659 regulation of cell fate specification IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0050865 regulation of cell activation IMP
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0031252 cell leading edge IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm2.1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0000036 absent semicircular canals "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm2.1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0000104 abnormal sphenoid bone morphology "malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000861 disorganized barrel cortex "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science:ISBN 0-8385-8034-3, J:64064]
Show

Allelic Composition: Smotm1Amc/Smotm2Amc,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi
Genetic Background: involves: C57BL/6J

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Htr7tm1Mrg/Htr7tm1Mrg
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0004310 small otic vesicle "reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0004449 absent presphenoid bone "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0004568 fusion of glossopharyngeal and vagus nerve "union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lmo4tm2.1Gan/Lmo4tm2.1Gan,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009594 abnormal corneocyte envelope morphology "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3tm1Bogi/Grhl3tm1Bogi,Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lmo4tm1Gan/Lmo4tm1Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0012686 everted embryonic neuroepithelium "an inside-out appearance of the embryonic neuroepithelium characteristic of defective primary neurulation resulting from failure of neural fold elevation; everted neural folds assume a convex instead of a concave morphology and fail to bend toward each other and fuse at the dorsal midline leading to exencephaly" [MGI:anna]
Show

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0012704 abnormal embryonic neuroepithelial cell proliferation "any anomaly in the ability of the cells of the embryonic neuroepithelium to undergo expansion by cell division" [CL:0000710, MGI:anna]
Show

Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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