ENSMUSG00000032698


Mus musculus

Features
Gene ID: ENSMUSG00000032698
  
Biological name :Lmo2
  
Synonyms : Lmo2 / P25801 / Rhombotin-2
  
Possible biological names infered from orthology : LIM domain only 2 / P25791
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E2
Gene start: 103957986
Gene end: 103981878
  
Corresponding Affymetrix probe sets: 10474201 (MoGene1.0st)   1454086_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106770
Ensembl peptide - ENSMUSP00000128317
Ensembl peptide - ENSMUSP00000122369
Ensembl peptide - ENSMUSP00000121927
Ensembl peptide - ENSMUSP00000117703
Ensembl peptide - ENSMUSP00000106773
Ensembl peptide - ENSMUSP00000106769
NCBI entrez gene - 16909     See in Manteia.
MGI - MGI:102811
RefSeq - XM_006498820
RefSeq - NM_001142335
RefSeq - NM_001142336
RefSeq - NM_001142337
RefSeq - NM_008505
RefSeq Peptide - NP_032531
RefSeq Peptide - NP_001135807
RefSeq Peptide - NP_001135808
RefSeq Peptide - NP_001135809
swissprot - A2BHP2
swissprot - A2BHP1
swissprot - A2BHP4
swissprot - A2BHP3
swissprot - P25801
swissprot - Q544Z2
swissprot - A2BHP5
Ensembl - ENSMUSG00000032698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmo2ENSDARG00000095019Danio rerio
 LMO2ENSGALG00000029892Gallus gallus
 LMO2ENSG00000135363Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611134
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022633
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*ENSMUSG0000002826626
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*ENSMUSG0000002693423
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*ENSMUSG0000001923021
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024721
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225820
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*ENSMUSG0000002689020
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*ENSMUSG0000009622519
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*ENSMUSG0000003231819
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*ENSMUSG0000002646819
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876519
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668618
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869818
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035162 embryonic hemopoiesis IGI
 biological_processGO:0042789 mRNA transcription by RNA polymerase II ISO
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0097067 cellular response to thyroid hormone stimulus ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex ISO
 cellular_componentGO:0032991 protein-containing complex IPI
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding ISO
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048037 cofactor binding ISO
 molecular_functionGO:0070888 E-box binding ISO


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012131 small visceral yolk sac "reduced size of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [MGI:anna]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013657 abnormal blood cell morphology "any structural anomaly of cells found in the blood" [CL:0000081]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013697 decreased granulocyte monocyte progenitor cell number "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0013705 decreased megakaryocyte-erythroid progenitor cell number "reduced number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr