ENSMUSG00000019230


Mus musculus

Features
Gene ID: ENSMUSG00000019230
  
Biological name :Lhx9
  
Synonyms : Lhx9 / LIM/homeobox protein Lhx9 / Q9WUH2
  
Possible biological names infered from orthology : LIM homeobox 9 / Q9NQ69
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 138825186
Gene end: 138848577
  
Corresponding Affymetrix probe sets: 10358272 (MoGene1.0st)   1419324_at (Mouse Genome 430 2.0 Array)   1429905_at (Mouse Genome 430 2.0 Array)   1431598_a_at (Mouse Genome 430 2.0 Array)   1441313_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142268
Ensembl peptide - ENSMUSP00000107657
Ensembl peptide - ENSMUSP00000107661
Ensembl peptide - ENSMUSP00000019374
Ensembl peptide - ENSMUSP00000036480
Ensembl peptide - ENSMUSP00000091198
NCBI entrez gene - 16876     See in Manteia.
MGI - MGI:1316721
RefSeq - XM_017318637
RefSeq - NM_001025565
RefSeq - NM_001042577
RefSeq - NM_010714
RefSeq - XM_006529170
RefSeq - XM_006529171
RefSeq - XM_006529172
RefSeq - XM_006529173
RefSeq - XM_017318628
RefSeq Peptide - NP_001020736
RefSeq Peptide - NP_001036042
RefSeq Peptide - NP_034844
swissprot - Q9WUH2
swissprot - A0A0A6YY42
Ensembl - ENSMUSG00000019230
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhx9ENSDARG00000056979Danio rerio
 LHX9ENSGALG00000002223Gallus gallus
 LHX9ENSG00000143355Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024770
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*ENSMUSG0000009622529
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*ENSMUSG0000002689028
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959525
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*ENSMUSG0000003231825
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869825
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668624
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225824
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876524
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*ENSMUSG0000002693424
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*ENSMUSG0000002646822
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*ENSMUSG0000002826616
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022615
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611115
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*ENSMUSG0000003269812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0035262 gonad morphogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0097380 dorsal spinal cord interneuron anterior axon guidance ISS
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gaatm1Rabn/Gaatm1Rabn,Tg(CMV-GAA*P545L)#Kjv/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lhx9tm1.1(cre/ERT2)Gan/Lhx9tm1.1(cre/ERT2)Gan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001939 secondary sex reversal "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003578 absent ovary "absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm2Arge/Igf1tm2.1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

Allelic Composition: Lhx2tm1Dra/Lhx2+,Lhx9tm1Dodd/Lhx9tm1Dodd
Genetic Background: Not Specified

Allelic Composition: Lhx2tm1Dra/Lhx2tm1Dra,Lhx9tm1Dodd/Lhx9+
Genetic Background: Not Specified

Allelic Composition: Lhx2tm1Dra/Lhx2+,Lhx9tm1Dodd/Lhx9tm1Dodd,Robo3tm1Matl/Robo3+
Genetic Background: Not Specified

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004895 vagina atrophy "wasting of the vagina due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005644 agonadal "denoting the absence of gonads" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005652 sex reversal "development of the reproductive system is inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx9tm1.1(cre/ERT2)Gan/Lhx9tm1.1(cre/ERT2)Gan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006415 absent testes "absence of the male reproductive glands containing the germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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