Manteia

ENSMUSG00000026686

Mus musculus

Features

Gene ID:	ENSMUSG00000026686

Biological name :	Lmx1a

Synonyms :	LIM homeobox transcription factor 1-alpha / Lmx1a / Q9JKU8

Possible biological names infered from orthology :	Q8TE12

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	H2.3
Gene start:	167689237
Gene end:	167848741

Corresponding Affymetrix probe sets:	10351443 (MoGene1.0st) 1421554_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000028003 Ensembl peptide - ENSMUSP00000107008 NCBI entrez gene - 110648 See in Manteia. MGI - MGI:1888519 RefSeq - XM_017321684 RefSeq - NM_033652 RefSeq - XM_006496611 RefSeq Peptide - NP_387501 swissprot - Q9JKU8 swissprot - Q543W2 Ensembl - ENSMUSG00000026686

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lmx1a	ENSDARG00000020354	Danio rerio
LMX1A	ENSGALG00000003424	Gallus gallus
LMX1A	ENSG00000162761	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*	ENSMUSG00000038765	67
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*	ENSMUSG00000026934	32
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*	ENSMUSG00000029595	30
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*	ENSMUSG00000018698	30
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*	ENSMUSG00000032318	29
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*	ENSMUSG00000026468	29
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*	ENSMUSG00000042258	28
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*	ENSMUSG00000019230	25
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*	ENSMUSG00000096225	24
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*	ENSMUSG00000026890	24
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*	ENSMUSG00000000247	24
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*	ENSMUSG00000028266	16
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*	ENSMUSG00000036111	15
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*	ENSMUSG00000030226	14
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*	ENSMUSG00000032698	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR001781	Zinc finger, LIM-type
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001558	regulation of cell growth	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007411	axon guidance	IMP
biological_process	GO:0007417	central nervous system development	IMP
biological_process	GO:0007420	brain development	IEA
biological_process	GO:0007613	memory	IGI
biological_process	GO:0007626	locomotory behavior	IGI
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0021542	dentate gyrus development	IMP
biological_process	GO:0021549	cerebellum development	IMP
biological_process	GO:0021766	hippocampus development	IMP
biological_process	GO:0021953	central nervous system neuron differentiation	IMP
biological_process	GO:0030182	neuron differentiation	IMP
biological_process	GO:0030901	midbrain development	IMP
biological_process	GO:0042048	olfactory behavior	IGI
biological_process	GO:0045665	negative regulation of neuron differentiation	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0050808	synapse organization	IGI
biological_process	GO:0071542	dopaminergic neuron differentiation	IMP
biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IC
biological_process	GO:1904948	midbrain dopaminergic neuron differentiation	IDA
biological_process	GO:1905426	positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation	IC
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Scn11a^tm1Wlf/Scn11a^tm1Wlf Genetic Background: B6.Cg-Scn11a^tm1Wlf Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd
MP:0000034	abnormal vestibule morphology	"malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd
MP:0000035	abnormal membranous labyrinth	"malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0000036	absent semicircular canals	"missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0000077	abnormal interparietal bone morphology	"malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0000350	abnormal cell proliferation	"anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Krt10^tm2Tmm/Krt10^tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0000373	belly spot	"the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mycn^tm2.1Nagy/Mycn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr-2J/Lmx1a^dr-2J Genetic Background: AKR/J Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^bsd/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0000566	synostosis	"osseous union of two bones that are not normally connected" [J:13049]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Scn11a^tm1Wlf/Scn11a^tm1Wlf Genetic Background: B6.Cg-Scn11a^tm1Wlf Allelic Composition: Lmx1a^dr-11J/Lmx1a^dr-11J Genetic Background: involves: C57BL/6J * CB17 * NOD
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Lmx1a^dr-2J/Lmx1a^dr-2J Genetic Background: AKR/J Allelic Composition: Lmx1a^dr-kjmi/Lmx1a^dr-kjmi Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J Allelic Composition: Lmx1a^dr-11J/Lmx1a^dr-11J Genetic Background: involves: C57BL/6J * CB17 * NOD Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0000808	abnormal hippocampus development	"improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0000828	abnormal fourth ventricle morphology	"malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ccr6^tm1.1Jmf/Ccr6^tm1.1Jmf Genetic Background: B6.129-Ccr6^tm1.1Jmf Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J,Lmx1b^tm1Rjo/Lmx1b^tm1Zfc,Tg(Lmx1a-cre)1Kjmi/0 Genetic Background: involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J,Lmx1b^tm1Rjo/Lmx1b^tm1Zfc,Tg(Lmx1a-cre)1Kjmi/0 Genetic Background: involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Lmx1a^dr-8J/Lmx1a^dr-8J Genetic Background: B6.C3-Pde6b^rd1 Hps4^le/J Allelic Composition: Lmx1a^dr-7J/Lmx1a^dr-7J Genetic Background: B10.A-H2^a H2-T18^a/SgSnJ Allelic Composition: Lmx1a^dr-kjmi/Lmx1a^dr-kjmi Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J,Lmx1b^tm1Rjo/Lmx1b^tm1Zfc,Tg(Lmx1a-cre)1Kjmi/0 Genetic Background: involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6
MP:0000854	abnormal cerebellum development	"malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J,Lmx1b^tm1Rjo/Lmx1b^tm1Zfc,Tg(Lmx1a-cre)1Kjmi/0 Genetic Background: involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6 Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3HeB/Fe * C57BL/6
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr-8J/Lmx1a^dr-8J Genetic Background: B6.C3-Pde6b^rd1 Hps4^le/J Allelic Composition: Lmx1a^dr-7J/Lmx1a^dr-7J Genetic Background: B10.A-H2^a H2-T18^a/SgSnJ Allelic Composition: Lmx1a^dr-kjmi/Lmx1a^dr-kjmi Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0000869	abnormal posterior vermis	"malformation in the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Lmx1a^dr-8J/Lmx1a^dr-8J Genetic Background: B6.C3-Pde6b^rd1 Hps4^le/J Allelic Composition: Lmx1a^dr-7J/Lmx1a^dr-7J Genetic Background: B10.A-H2^a H2-T18^a/SgSnJ Allelic Composition: Lmx1a^dr-kjmi/Lmx1a^dr-kjmi Genetic Background: involves: 129 * C57BL/6J
MP:0000923	abnormal roof plate morphology	"malformation or absence of a transient group of neuroepithelial cells located at the dorsal midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0000933	abnormal rhombomere morphology	"malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0001073	abnormal glossopharyngeal nerve morphology	"malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0001096	abnormal glossopharyngeal ganglion morphology	"malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0001121	uterine hypoplasia	"reduced size of the uterus due to decreased cell number" [J:45065]	Show Allelic Composition: Lmx1a^dr-2J/Lmx1a^dr-2J Genetic Background: AKR/J Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Scn11a^tm1Wlf/Scn11a^tm1Wlf Genetic Background: B6.Cg-Scn11a^tm1Wlf Allelic Composition: Lmx1a^dr-11J/Lmx1a^dr-11J Genetic Background: involves: C57BL/6J * CB17 * NOD
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Plcg2^Ali5/Plcg2⁺,Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5 Allelic Composition: Lmx1a^dr-kjmi/Lmx1a^dr-kjmi Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr-2J/Lmx1a^dr-2J Genetic Background: AKR/J Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J
MP:0001395	bi-directional circling	"circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J Allelic Composition: Lmx1a^dr-11J/Lmx1a^dr-11J Genetic Background: involves: C57BL/6J * CB17 * NOD
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Plcg2^Ali5/Plcg2⁺,Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5 Allelic Composition: Lmx1a^dr-kjmi/Lmx1a^dr-kjmi Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plcg2^Ali5/Plcg2⁺,Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5 Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Plcg2^Ali5/Plcg2⁺,Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5 Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0001526	abnormal placing response	"altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr-2J/Lmx1a^dr-2J Genetic Background: AKR/J Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Krt10^tm2Tmm/Krt10^tm2Tmm Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hcn2^ap/Hcn2⁺ Genetic Background: DW/Pas-Hcn2^ap
MP:0002161	abnormal fertility/fecundity	"reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scn11a^tm1Wlf/Scn11a^tm1Wlf Genetic Background: B6.Cg-Scn11a^tm1Wlf Allelic Composition: Lmx1a^dr-11J/Lmx1a^dr-11J Genetic Background: involves: C57BL/6J * CB17 * NOD
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Tg(Slc6a3-cre/ERT2)1Span/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002428	abnormal semicircular canal	"anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0002671	belted	"the appearance of a stripe of white fur around the circumference of the abdomen" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J
MP:0002800	abnormal short-term recognition memory	"defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0002862	altered righting response	"altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J
MP:0002938	white spotting	"the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-kjmi/Lmx1a^dr-kjmi Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J Allelic Composition: Lmx1a^dr-6J/Lmx1a^dr-6J Genetic Background: C3H/HeJ-Lmx1a^dr-6J
MP:0002978	absent otoliths	"absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0003008	enhanced long term potentiation	"greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0003054	spina bifida	"common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0003091	abnormal cell migration	"defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0003172	abnormal lysosome physiology	"ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0003938	abnormal ear development	"developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0004289	abnormal bony labyrinth	"any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0004315	absent saccule	"absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0004369	absent utricle	"absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0004393	abnormal cochlear inner hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0004426	abnormal cochlear labyrinth	"any structural abnormality in the portion of the membranous labyrinth concerned with the sense of hearing (vs. the vestibular labyrinth, which is concerned with the sense of equilibration) and innervated by the cochlear nerve; it is located within the cochlea of the bony labyrinth, and consists of the cochlear duct, which contains the spiral organ " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0004427	abnormal vestibular labyrinth	"any structural abnormality in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0004750	syndromic hearing loss	"a form of progressive hearing loss that is usually associated with malformations of the external ear and other inherited signs and symptoms " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0004792	abnormal synaptic vesicle number	"anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0005058	abnormal lysosome morphology	"anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0005226	abnormal vertebral arch development	"anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0005307	head tossing	"compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Lmx1a^dr-2J/Lmx1a^dr-2J Genetic Background: AKR/J Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J Allelic Composition: Lmx1a^dr-11J/Lmx1a^dr-11J Genetic Background: involves: C57BL/6J * CB17 * NOD Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0005643	decreased dopamine level	"less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Tg(Slc6a3-cre/ERT2)1Span/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006012	dilated endolymphatic duct	"an expansion in the volume of the endolymphatic duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0006014	dilated endolymphatic sac	"an expansion in the volume of the endolymphatic sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]	Show Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0006030	abnormal otic vesicle formation	"anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0006089	abnormal saccule morphology	"malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0006090	abnormal utricle morphology	"malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0006281	abnormal tail development	"anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0006286	inner ear hypoplasia	"underdevelopment or reduced size of inner ear structures, usually due to decreased cell number" [J:83662, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0006358	absent pinna reflex	"complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0008260	abnormal autophagy	"abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0008267	abnormal hippocampus CA3 region morphology		Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0008284	abnormal hippocampus pyramidal cell layer		Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0008307	short scala media	"reduced length of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0008544	impaired olfaction	"reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0008571	abnormal synaptic bouton morphology	"any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Tg(Slc6a3-cre/ERT2)1Span/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008762	embryonic lethality	"death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^tm1.1Tpe/Lmx1a^tm1.1Tpe Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008854	bleb	"presence of a blister-like, nearly hemispherical structure formed during embryonic development filled with air, serous fluid or blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0009393	abnormal resting posture	"atypical position of the limbs compared to normal carriage when the body is inactive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-sst/Lmx1a^dr-sst Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J
MP:0009538	abnormal synapse morphology	"any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]	Show Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe,Lmx1b^tm1Zfc/Lmx1b^tm1Zfc,Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0009719	reduced cerebellar foliation	"the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mertk^nmf12/Mertk^nmf12,Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: involves: C57BL/6J
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Mycn^tm2.1Nagy/Mycn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J
MP:0011448	decreased dopaminergic neuron number	"fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]	Show Allelic Composition: Mertk^nmf12/Mertk^nmf12,Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: involves: C57BL/6J Allelic Composition: Lmx1a^tm1.1Tpe/Lmx1a^tm1.1Tpe Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Lmx1a^tm1Ics/Lmx1a⁺,Lmx1b^tm1Rjo/Lmx1b⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Lmx1a^tm1Ics/Lmx1a^tm1Ics,Lmx1b^tm1Rjo/Lmx1b⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J Genetic Background: 129P3/J-Lmx1a^dr-10J/J Allelic Composition: Lmx1a^bsd/Lmx1a^bsd Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^mtl/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Lmx1a^bsd/Lmx1a^mtl Genetic Background: involves: 129S5/SvEvBrd
MP:0012792	abnormal rhombomere 3 morphology	"any structural anomaly of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005507]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0012796	abnormal rhombomere 4 morphology	"any structural anomaly of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005511]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6
MP:0012800	abnormal rhombomere 5 morphology	"any structural anomaly of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005515]	Show Allelic Composition: Lmx1a^dr-J/Lmx1a^dr-J Genetic Background: involves: C3H * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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