ENSG00000162761


Homo sapiens

Features
Gene ID: ENSG00000162761
  
Biological name :LMX1A
  
Synonyms : LIM homeobox transcription factor 1 alpha / LMX1A / Q8TE12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.3
Gene start: 165201867
Gene end: 165356715
  
Corresponding Affymetrix probe sets: 1553541_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000294816
Ensembl peptide - ENSP00000340226
Ensembl peptide - ENSP00000356868
NCBI entrez gene - 4009     See in Manteia.
OMIM - 600298
RefSeq - XM_011509540
RefSeq - NM_001174069
RefSeq - NM_177398
RefSeq - XM_011509538
RefSeq Peptide - NP_001167540
RefSeq Peptide - NP_796372
swissprot - Q8TE12
Ensembl - ENSG00000162761
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmx1aENSDARG00000020354Danio rerio
 LMX1AENSGALG00000003424Gallus gallus
 Lmx1aENSMUSG00000026686Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LMX1B / O60663 / LIM homeobox transcription factor 1 betaENSG0000013694467
LHX5 / Q9H2C1 / LIM homeobox 5ENSG0000008911632
LHX3 / Q9UBR4 / LIM homeobox 3ENSG0000010718732
LHX1 / P48742 / LIM homeobox 1ENSG0000027370631
ISL2 / Q96A47 / ISL LIM homeobox 2ENSG0000015955629
ISL1 / P61371 / ISL LIM homeobox 1ENSG0000001608229
LHX4 / Q969G2 / LIM homeobox 4ENSG0000012145429
LHX8 / Q68G74 / LIM homeobox 8ENSG0000016262426
LHX9 / Q9NQ69 / LIM homeobox 9ENSG0000014335525
LHX6 / Q9UPM6 / LIM homeobox 6ENSG0000010685224
LHX2 / P50458 / LIM homeobox 2ENSG0000010668924
LMO4 / P61968 / LIM domain only 4ENSG0000014301316
LMO1 / P25800 / LIM domain only 1ENSG0000016640715
LMO3 / Q8TAP4 / LIM domain only 3ENSG0000004854014
LMO2 / P25791 / LIM domain only 2ENSG0000013536311


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0021542 dentate gyrus development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021953 central nervous system neuron differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0042048 olfactory behavior IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0071542 dopaminergic neuron differentiation TAS
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation TAS
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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