ENSG00000159556


Homo sapiens

Features
Gene ID: ENSG00000159556
  
Biological name :ISL2
  
Synonyms : ISL2 / ISL LIM homeobox 2 / Q96A47
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q24.3
Gene start: 76336724
Gene end: 76342476
  
Corresponding Affymetrix probe sets: 232352_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000290759
Ensembl peptide - ENSP00000453837
NCBI entrez gene - 64843     See in Manteia.
OMIM - 609481
RefSeq - XM_017022505
RefSeq - NM_145805
RefSeq Peptide - NP_665804
swissprot - Q96A47
swissprot - H0YN25
Ensembl - ENSG00000159556
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isl2aENSDARG00000003971Danio rerio
 isl2bENSDARG00000053499Danio rerio
 ISL2ENSGALG00000033391Gallus gallus
 Isl2ENSMUSG00000032318Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ISL1 / P61371 / ISL LIM homeobox 1ENSG0000001608274
LMX1B / O60663 / LIM homeobox transcription factor 1 betaENSG0000013694431
LMX1A / Q8TE12 / LIM homeobox transcription factor 1 alphaENSG0000016276131
LHX5 / Q9H2C1 / LIM homeobox 5ENSG0000008911629
LHX3 / Q9UBR4 / LIM homeobox 3ENSG0000010718728
LHX1 / P48742 / LIM homeobox 1ENSG0000027370628
LHX9 / Q9NQ69 / LIM homeobox 9ENSG0000014335528
LHX2 / P50458 / LIM homeobox 2ENSG0000010668927
LHX4 / Q969G2 / LIM homeobox 4ENSG0000012145427
LHX6 / Q9UPM6 / LIM homeobox 6ENSG0000010685226
LHX8 / Q68G74 / LIM homeobox 8ENSG0000016262425
LMO4 / P61968 / LIM domain only 4ENSG0000014301318
LMO1 / P25800 / LIM domain only 1ENSG0000016640716
LMO3 / Q8TAP4 / LIM domain only 3ENSG0000004854014
LMO2 / P25791 / LIM domain only 2ENSG0000013536312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IEA
 biological_processGO:0021524 visceral motor neuron differentiation IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048666 neuron development TAS
 biological_processGO:0048935 peripheral nervous system neuron development TAS
 cellular_componentGO:0005634 nucleus IC
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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