ENSG00000166407


Homo sapiens

Features
Gene ID: ENSG00000166407
  
Biological name :LMO1
  
Synonyms : LIM domain only 1 / LMO1 / P25800
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 8224304
Gene end: 8268716
  
Corresponding Affymetrix probe sets: 206718_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435456
Ensembl peptide - ENSP00000338207
Ensembl peptide - ENSP00000404538
NCBI entrez gene - 4004     See in Manteia.
OMIM - 186921
RefSeq - XM_011520099
RefSeq - NM_001270428
RefSeq - NM_002315
RefSeq - XM_006718228
RefSeq - XM_011520098
RefSeq Peptide - NP_001257357
RefSeq Peptide - NP_002306
swissprot - P25800
swissprot - E9PK83
Ensembl - ENSG00000166407
  
Related genetic diseases (OMIM): 186921 - Leukemia, T-cell acute lymphoblastic
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Lmo1ENSMUSG00000036111Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LMO3 / Q8TAP4 / LIM domain only 3ENSG0000004854072
LMO2 / P25791 / LIM domain only 2ENSG0000013536350
LMO4 / P61968 / LIM domain only 4ENSG0000014301345
LHX9 / Q9NQ69 / LIM homeobox 9ENSG0000014335538
LHX2 / P50458 / LIM homeobox 2ENSG0000010668938
LHX4 / Q969G2 / LIM homeobox 4ENSG0000012145437
LMX1A / Q8TE12 / LIM homeobox transcription factor 1 alphaENSG0000016276137
ISL2 / Q96A47 / ISL LIM homeobox 2ENSG0000015955636
LHX3 / Q9UBR4 / LIM homeobox 3ENSG0000010718736
LMX1B / O60663 / LIM homeobox transcription factor 1 betaENSG0000013694435
LHX6 / Q9UPM6 / LIM homeobox 6ENSG0000010685235
ISL1 / P61371 / ISL LIM homeobox 1ENSG0000001608234
LHX8 / Q68G74 / LIM homeobox 8ENSG0000016262433
LHX1 / P48742 / LIM homeobox 1ENSG0000027370631
LHX5 / Q9H2C1 / LIM homeobox 5ENSG0000008911629


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046013 regulation of T cell homeostatic proliferation IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0004375 Neoplasia of the nervous system 
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 HP:0011976 Elevated urinary catecholamines "An increased concentration of `catecholamine` (CHEBI:33567) in the urine." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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