ENSG00000135363


Homo sapiens

Features
Gene ID: ENSG00000135363
  
Biological name :LMO2
  
Synonyms : LIM domain only 2 / LMO2 / P25791
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p13
Gene start: 33858576
Gene end: 33892289
  
Corresponding Affymetrix probe sets: 204249_s_at (Human Genome U133 Plus 2.0 Array)   231049_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257818
Ensembl peptide - ENSP00000379175
Ensembl peptide - ENSP00000401967
NCBI entrez gene - 4005     See in Manteia.
OMIM - 180385
RefSeq - XM_017017733
RefSeq - NM_001142315
RefSeq - NM_001142316
RefSeq - NM_005574
RefSeq - XM_017017729
RefSeq - XM_017017730
RefSeq - XM_017017731
RefSeq - XM_017017732
RefSeq - XM_005252921
RefSeq - XM_017017727
RefSeq - XM_017017728
RefSeq Peptide - NP_001135788
RefSeq Peptide - NP_005565
RefSeq Peptide - NP_001135787
swissprot - P25791
Ensembl - ENSG00000135363
  
Related genetic diseases (OMIM): 180385 - Leukemia, acute T-cell
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmo2ENSDARG00000095019Danio rerio
 LMO2ENSGALG00000029892Gallus gallus
 Lmo2ENSMUSG00000032698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LMO1 / P25800 / LIM domain only 1ENSG0000016640734
LMO3 / Q8TAP4 / LIM domain only 3ENSG0000004854029
LMO4 / P61968 / LIM domain only 4ENSG0000014301326
LHX3 / Q9UBR4 / LIM homeobox 3ENSG0000010718722
LMX1B / O60663 / LIM homeobox transcription factor 1 betaENSG0000013694421
LHX2 / P50458 / LIM homeobox 2ENSG0000010668921
LHX9 / Q9NQ69 / LIM homeobox 9ENSG0000014335521
ISL1 / P61371 / ISL LIM homeobox 1ENSG0000001608220
LHX8 / Q68G74 / LIM homeobox 8ENSG0000016262419
LHX4 / Q969G2 / LIM homeobox 4ENSG0000012145419
LHX6 / Q9UPM6 / LIM homeobox 6ENSG0000010685219
LMX1A / Q8TE12 / LIM homeobox transcription factor 1 alphaENSG0000016276119
ISL2 / Q96A47 / ISL LIM homeobox 2ENSG0000015955619
LHX1 / P48742 / LIM homeobox 1ENSG0000027370618
LHX5 / Q9H2C1 / LIM homeobox 5ENSG0000008911617


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IDA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048037 cofactor binding IPI
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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