ENSG00000089116


Homo sapiens

Features
Gene ID: ENSG00000089116
  
Biological name :LHX5
  
Synonyms : LHX5 / LIM homeobox 5 / Q9H2C1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.13
Gene start: 113462034
Gene end: 113472280
  
Corresponding Affymetrix probe sets: 208333_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261731
NCBI entrez gene - 64211     See in Manteia.
OMIM - 605992
RefSeq - NM_022363
RefSeq Peptide - NP_071758
swissprot - Q9H2C1
Ensembl - ENSG00000089116
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhx5ENSDARG00000057936Danio rerio
 LHX5ENSGALG00000008303Gallus gallus
 Lhx5ENSMUSG00000029595Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LHX1 / P48742 / LIM homeobox 1ENSG0000027370675
LHX3 / Q9UBR4 / LIM homeobox 3ENSG0000010718738
LHX4 / Q969G2 / LIM homeobox 4ENSG0000012145435
LMX1A / Q8TE12 / LIM homeobox transcription factor 1 alphaENSG0000016276130
LMX1B / O60663 / LIM homeobox transcription factor 1 betaENSG0000013694428
LHX2 / P50458 / LIM homeobox 2ENSG0000010668927
ISL1 / P61371 / ISL LIM homeobox 1ENSG0000001608226
ISL2 / Q96A47 / ISL LIM homeobox 2ENSG0000015955626
LHX9 / Q9NQ69 / LIM homeobox 9ENSG0000014335525
LHX6 / Q9UPM6 / LIM homeobox 6ENSG0000010685223
LHX8 / Q68G74 / LIM homeobox 8ENSG0000016262422
LMO4 / P61968 / LIM domain only 4ENSG0000014301314
LMO1 / P25800 / LIM domain only 1ENSG0000016640711
LMO3 / Q8TAP4 / LIM domain only 3ENSG0000004854011
LMO2 / P25791 / LIM domain only 2ENSG0000013536310


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0021527 spinal cord association neuron differentiation IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021846 cell proliferation in forebrain IEA
 biological_processGO:0021879 forebrain neuron differentiation IEA
 biological_processGO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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