ENSG00000106689


Homo sapiens

Features
Gene ID: ENSG00000106689
  
Biological name :LHX2
  
Synonyms : LHX2 / LIM homeobox 2 / P50458
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q33.3
Gene start: 124001670
Gene end: 124033301
  
Corresponding Affymetrix probe sets: 206140_at (Human Genome U133 Plus 2.0 Array)   211219_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362717
Ensembl peptide - ENSP00000394978
Ensembl peptide - ENSP00000453448
Ensembl peptide - ENSP00000476200
NCBI entrez gene - 9355     See in Manteia.
OMIM - 603759
RefSeq - XM_006717323
RefSeq - NM_004789
RefSeq Peptide - NP_004780
swissprot - H0YM35
swissprot - P50458
swissprot - U3KQT5
swissprot - H7C0H1
Ensembl - ENSG00000106689
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Lhx2ENSMUSG00000000247Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LHX9 / Q9NQ69 / LIM homeobox 9ENSG0000014335568
LHX6 / Q9UPM6 / LIM homeobox 6ENSG0000010685228
LHX5 / Q9H2C1 / LIM homeobox 5ENSG0000008911627
LHX8 / Q68G74 / LIM homeobox 8ENSG0000016262426
LHX3 / Q9UBR4 / LIM homeobox 3ENSG0000010718725
LHX1 / P48742 / LIM homeobox 1ENSG0000027370625
ISL2 / Q96A47 / ISL LIM homeobox 2ENSG0000015955624
ISL1 / P61371 / ISL LIM homeobox 1ENSG0000001608223
LMX1B / O60663 / LIM homeobox transcription factor 1 betaENSG0000013694422
LHX4 / Q969G2 / LIM homeobox 4ENSG0000012145422
LMX1A / Q8TE12 / LIM homeobox transcription factor 1 alphaENSG0000016276122
LMO4 / P61968 / LIM domain only 4ENSG0000014301315
LMO1 / P25800 / LIM domain only 1ENSG0000016640715
LMO3 / Q8TAP4 / LIM domain only 3ENSG0000004854014
LMO2 / P25791 / LIM domain only 2ENSG0000013536312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0021978 telencephalon regionalization IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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