ENSMUSG00000032318


Mus musculus

Features
Gene ID: ENSMUSG00000032318
  
Biological name :Isl2
  
Synonyms : Insulin enhancer protein ISL-2 / Isl2 / Q9CXV0
  
Possible biological names infered from orthology : ISL LIM homeobox 2 / Q96A47
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 55538672
Gene end: 55546180
  
Corresponding Affymetrix probe sets: 10585535 (MoGene1.0st)   1418676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139485
Ensembl peptide - ENSMUSP00000034869
Ensembl peptide - ENSMUSP00000109929
Ensembl peptide - ENSMUSP00000130638
NCBI entrez gene - 104360     See in Manteia.
MGI - MGI:109156
RefSeq - NM_027397
RefSeq - XM_006510756
RefSeq Peptide - NP_081673
swissprot - A0A087WNT5
swissprot - Q0VAX2
swissprot - Q9CXV0
Ensembl - ENSMUSG00000032318
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isl2aENSDARG00000003971Danio rerio
 isl2bENSDARG00000053499Danio rerio
 ISL2ENSGALG00000033391Gallus gallus
 ISL2ENSG00000159556Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225873
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876531
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668631
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959528
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024728
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*ENSMUSG0000002693428
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*ENSMUSG0000001923028
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869828
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*ENSMUSG0000002646827
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*ENSMUSG0000002689026
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*ENSMUSG0000009622524
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*ENSMUSG0000002826618
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611116
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022615
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*ENSMUSG0000003269812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IGI
 biological_processGO:0021524 visceral motor neuron differentiation IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0048663 neuron fate commitment IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mnx1tm1Jhk/Mnx1tm1Jhk,Isl2tm2Slp/Isl2tm2Slp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+,Tg(Mnx1-GFP)1Slp/?
Genetic Background: Not Specified

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Mnx1tm1Jhk/Mnx1tm1Jhk,Isl2tm2Slp/Isl2tm2Slp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001108 absent Schwann cells "missing cells that sheath the axons of the peripheral nervous system" [J:43515]
Show

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Trp53tm5Xu/Trp53tm5Xu
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax3Sp-7H/Pax3Sp-7H
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Isl2tm1Gan/Isl2tm1Gan
Genetic Background: Not Specified

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mnx1tm1Jhk/Mnx1tm1Jhk,Isl2tm2Slp/Isl2tm2Slp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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