ENSMUSG00000026934


Mus musculus

Features
Gene ID: ENSMUSG00000026934
  
Biological name :Lhx3
  
Synonyms : Lhx3 / LIM homeobox protein 3 / P50481
  
Possible biological names infered from orthology : LIM homeobox 3 / Q9UBR4
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 26200212
Gene end: 26208289
  
Corresponding Affymetrix probe sets: 10480912 (MoGene1.0st)   1421753_a_at (Mouse Genome 430 2.0 Array)   1425041_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028302
Ensembl peptide - ENSMUSP00000056822
NCBI entrez gene - 16871     See in Manteia.
MGI - MGI:102673
RefSeq - XM_011239031
RefSeq - NM_001039653
RefSeq - NM_010711
RefSeq Peptide - NP_001034742
RefSeq Peptide - NP_034841
swissprot - P50481
swissprot - A2ALD8
Ensembl - ENSMUSG00000026934
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LHX3ENSDARG00000003803Danio rerio
 LHX3ENSGALG00000003928Gallus gallus
 LHX3ENSG00000107187Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*ENSMUSG0000002646862
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959538
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869837
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668630
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876529
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024725
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*ENSMUSG0000003231825
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225825
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*ENSMUSG0000002689024
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*ENSMUSG0000001923023
Lhx8 / O35652 / LIM/homeobox protein Lhx8 / Q68G74* / LIM homeobox 8*ENSMUSG0000009622522
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*ENSMUSG0000002826615
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022614
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611114
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*ENSMUSG0000003269813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008045 motor neuron axon guidance IGI
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IGI
 biological_processGO:0021521 ventral spinal cord interneuron specification IDA
 biological_processGO:0021526 medial motor column neuron differentiation IGI
 biological_processGO:0021527 spinal cord association neuron differentiation IDA
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030324 lung development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048839 inner ear development IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm1(tTA)Roos/?,Lhx3tm1(cre)Slp/Lhx3+,Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001070 abnormal abducens nerve morphology "any anomaly, deformity, or malformation of the 6th cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tnkstm1.1Yjc/Tnks+,Tnks2tm1.1Yjc/Tnks2tm1.1Yjc
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002774 small prostate "reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002779 abnormal sex gland secretion "malfunction of the production and/or release of hormones from a cell or a gland of the reproductive system " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003965 abnormal pituitary hormone level "aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(tTA)Roos/?,Lhx3tm1(cre)Slp/Lhx3+,Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm2.1Desi/Rag2tm2.1Desi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005128 decreased adrenocorticotropin level "decreased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005132 decreased luteinizing hormone level "lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005138 decreased prolactin level "less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008299 adrenal cortical hyperplasia "overdevelopment of the thick outer layer of the adrenal gland that produces and secretes steroid hormones, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008320 absent adenohypophysis "absence of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0008327 abnormal corticotroph morphology "any structural anomaly of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008330 absent somatotrophs "absence of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008332 decreased lactotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008333 absent lactotrophs "absence of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008339 absent thyrotrophs "absence of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008365 adenohypophysis hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, of the anterior lobe of the pituitary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008367 absent pituitary intermediate lobe "absence of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008368 small pituitary intermediate lobe "reduced size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0009205 abnormal internal male genitalia morphology "any structural anomaly of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Lhx3tm1.1Sjr/Lhx3tm1.1Sjr
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013351 abnormal Rathke s pouch development "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0013352 abnormal Rathke s pouch apoptosis "any change in the timing or number of Rathke s pouch cells undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025223 Ldb1 / P70662 / LIM domain-binding protein 1 / Q86U70* / LIM domain binding 1*  / complex
 ENSMUSG00000026934 Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*  / complex
 ENSMUSG00000042258 Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*  / complex






 

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