ENSMUSG00000096225


Mus musculus

Features
Gene ID: ENSMUSG00000096225
  
Biological name :Lhx8
  
Synonyms : Lhx8 / LIM/homeobox protein Lhx8 / O35652
  
Possible biological names infered from orthology : LIM homeobox 8 / Q68G74
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H4
Gene start: 154306294
Gene end: 154330659
  
Corresponding Affymetrix probe sets: 10502961 (MoGene1.0st)   1427300_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145516
Ensembl peptide - ENSMUSP00000136047
Ensembl peptide - ENSMUSP00000144708
Ensembl peptide - ENSMUSP00000145485
NCBI entrez gene - 16875     See in Manteia.
MGI - MGI:1096343
RefSeq - XM_017319470
RefSeq - NM_010713
RefSeq - XM_006501072
RefSeq Peptide - NP_034843
swissprot - A0A0N4SUJ5
swissprot - O35652
swissprot - H3BJ54
swissprot - A0A0N4SWH1
Ensembl - ENSMUSG00000096225
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhx8aENSDARG00000002330Danio rerio
 lhx8bENSDARG00000042145Danio rerio
 LHX8ENSGALG00000011369Gallus gallus
 LHX8ENSG00000162624Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhx6 / Q9R1R0 / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA. / Q9UPM6* / LIM homeobox 6*ENSMUSG0000002689055
Lhx9 / Q9WUH2 / LIM/homeobox protein Lhx9 / Q9NQ69* / LIM homeobox 9*ENSMUSG0000001923031
Lhx2 / Q9Z0S2 / LIM/homeobox protein Lhx2 / P50458* / LIM homeobox 2*ENSMUSG0000000024728
Lmx1b / LIM homeobox transcription factor 1 beta / O60663*ENSMUSG0000003876527
Isl1 / P61372 / Insulin enhancer protein ISL-1 / P61371* / ISL LIM homeobox 1*ENSMUSG0000004225825
Lmx1a / Q9JKU8 / LIM homeobox transcription factor 1-alpha / Q8TE12*ENSMUSG0000002668625
Lhx4 / P53776 / LIM/homeobox protein Lhx4 / Q969G2* / LIM homeobox 4*ENSMUSG0000002646824
Isl2 / Q9CXV0 / Insulin enhancer protein ISL-2 / Q96A47* / ISL LIM homeobox 2*ENSMUSG0000003231824
Lhx3 / P50481 / LIM homeobox protein 3 / Q9UBR4* / LIM homeobox 3*ENSMUSG0000002693424
Lhx1 / P63006 / LIM/homeobox protein Lhx1 / P48742* / LIM homeobox 1*ENSMUSG0000001869823
Lhx5 / P61375 / LIM homeobox protein 5 / Q9H2C1* / LIM homeobox 5*ENSMUSG0000002959522
Lmo4 / P61969 / LIM domain transcription factor LMO4 / P61968* / LIM domain only 4*ENSMUSG0000002826616
Lmo1 / Q924W9 / Rhombotin-1 / P25800* / LIM domain only 1*ENSMUSG0000003611114
Lmo3 / Q8BZL8 / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA. / Q8TAP4* / LIM domain only 3*ENSMUSG0000003022614
Lmo2 / P25801 / Rhombotin-2 / P25791* / LIM domain only 2*ENSMUSG0000003269812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0021879 forebrain neuron differentiation IMP
 biological_processGO:0021884 forebrain neuron development IGI
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 cellular_componentGO:0001674 female germ cell nucleus IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ralbp1Gt(OST359995)Lex/Ralbp1+
Genetic Background: involves: 129S5/SvEvBrd * C57BL

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Lhx8tm1Awan/Lhx8tm1Awan
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm2.1Vpa,Tg(Chat-cre)GM24Gsat/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Lhx8tm1Awan/Lhx8tm1Awan
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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