ENSDARG00000003971


Danio rerio

Features
Gene ID: ENSDARG00000003971
  
Biological name :isl2a
  
Synonyms : isl2a / ISL LIM homeobox 2a / P53406
  
Possible biological names infered from orthology : Insulin enhancer protein ISL-2 / ISL2 / ISL LIM homeobox 2 / Q96A47 / Q9CXV0
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 32746014
Gene end: 32751982
  
Corresponding Affymetrix probe sets: Dr.281.1.S1_at (Zebrafish Array)   NM_130970_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000020636
NCBI entrez gene - 30157     See in Manteia.
RefSeq - NM_130970
RefSeq Peptide - NP_571045
swissprot - B3DH43
swissprot - P53406
ZFIN ID - ZDB-GENE-980526-562
Ensembl - ENSDARG00000003971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ISL2ENSGALG00000033391Gallus gallus
 ISL2ENSG00000159556Homo sapiens
 Isl2ENSMUSG00000032318Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
isl2b / P53407 / ISL LIM homeobox 2b / ISL2* / Q9CXV0* / Q96A47* / ISL LIM homeobox 2* / Insulin enhancer protein ISL-2 *ENSDARG0000005349989
isl1 / P53405 / ISL LIM homeobox 1 / P61371* / P61372* / Insulin enhancer protein ISL-1 *ENSDARG0000000402375
isl1l / islet1, likeENSDARG0000002105547
lmx1ba / LIM homeobox transcription factor 1, beta a / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000010481530
lmx1al / LIM homeobox transcription factor 1, alpha-likeENSDARG0000007791529
lmx1bb / LIM homeobox transcription factor 1, beta b / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000006836528
lmx1a / LIM homeobox transcription factor 1, alpha / Q8TE12* / Q9JKU8*ENSDARG0000002035428
lhx9 / Q1LWV4 / LIM homeobox 9 / Q9WUH2* / Q9NQ69* / LIM/homeobox protein Lhx9 *ENSDARG0000005697928
lhx5 / P52889 / LIM homeobox 5 / Q9H2C1* / P61375* / LIM homeobox protein 5*ENSDARG0000005793628
lhx1a / Q90476 / LIM homeobox 1a / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000001401828
lhx2b / LIM homeobox 2bENSDARG0000003122228
lhx1b / LIM homeobox 1b / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000000794427
lhx4 / LIM homeobox 4 / P53776* / Q969G2* / LIM/homeobox protein Lhx4 *ENSDARG0000003945826
LHX3 / LIM homeobox 3 / Q9UBR4*ENSDARG0000000380326
lhx6 / LIM homeobox 6 / Q9R1R0* / Q9UPM6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000000689625
lhx8a / LIM homeobox 8a / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000000233025
lhx2a / LIM homeobox 2aENSDARG0000003796423
lhx8b / LIM homeobox 8b / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000004214523
si:ch211-236k19.2 / LHX6* / Q9R1R0* / Q9UPM6* / LIM homeobox 6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000005216521
lmo4b / LIM domain only 4b / LMO4* / P61968* / P61969* / LIM domain only 4* / LIM domain transcription factor LMO4 *ENSDARG0000005474917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0031017 exocrine pancreas development IGI
 biological_processGO:0035476 angioblast cell migration IMP
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta mislocalised , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein decreased distribution , abnormal
posterior cardinal vein blood vessel endothelial cell decreased amount , abnormal
Show

 ZFA:0001061 intersegmental artery intersegmental artery sprouting angiogenesis decreased process quality , abnormal
intersegmental artery blood vessel endothelial cell decreased amount , abnormal
intersegmental artery blood vessel endothelial cell amount , ameliorated
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism viability , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0005040 posterior lateral mesoderm posterior lateral mesoderm angioblastic mesenchymal cell spatial pattern , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axon guidance physical quality of a process , abnormal
CaP motoneuron axon truncated , abnormal
CaP motoneuron axon branchiness , abnormal
CaP motoneuron axon extension decreased process quality , abnormal
CaP motoneuron axon decreased length , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron decreased amount , abnormal
secondary motor neuron axon decreased amount , abnormal
secondary motor neuron absent , abnormal
Show

 ZFA:0009258 angioblastic mesenchymal cell angioblastic mesenchymal cell irregular spatial pattern , abnormal
angioblastic mesenchymal cell mislocalised , abnormal
angioblastic mesenchymal cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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