ENSDARG00000031222


Danio rerio

Features
Gene ID: ENSDARG00000031222
  
Biological name :lhx2b
  
Synonyms : lhx2b / LIM homeobox 2b
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 3085120
Gene end: 3101392
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000120466
Ensembl peptide - ENSDARP00000123264
NCBI entrez gene - 791744     See in Manteia.
RefSeq - NM_001040010
RefSeq Peptide - NP_001035099
swissprot - F6NJE9
swissprot - B0R107
ZFIN ID - ZDB-GENE-051220-1
Ensembl - ENSDARG00000031222
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LHX2ENSGALG00000001124Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lhx9 / Q1LWV4 / LIM homeobox 9 / Q9WUH2* / Q9NQ69* / LIM/homeobox protein Lhx9 *ENSDARG0000005697966
lhx2a / LIM homeobox 2aENSDARG0000003796443
lhx6 / LIM homeobox 6 / Q9R1R0* / Q9UPM6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000000689627
lhx1a / Q90476 / LIM homeobox 1a / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000001401824
lhx5 / P52889 / LIM homeobox 5 / Q9H2C1* / P61375* / LIM homeobox protein 5*ENSDARG0000005793624
lhx8a / LIM homeobox 8a / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000000233024
isl2b / P53407 / ISL LIM homeobox 2b / ISL2* / Q9CXV0* / Q96A47* / ISL LIM homeobox 2* / Insulin enhancer protein ISL-2 *ENSDARG0000005349923
isl2a / P53406 / ISL LIM homeobox 2a / ISL2* / Q96A47* / ISL LIM homeobox 2*ENSDARG0000000397123
lmx1al / LIM homeobox transcription factor 1, alpha-likeENSDARG0000007791522
lhx1b / LIM homeobox 1b / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000000794422
lmx1bb / LIM homeobox transcription factor 1, beta b / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000006836522
lmx1a / LIM homeobox transcription factor 1, alpha / Q8TE12* / Q9JKU8*ENSDARG0000002035422
lmx1ba / LIM homeobox transcription factor 1, beta a / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000010481522
lhx4 / LIM homeobox 4 / P53776* / Q969G2* / LIM/homeobox protein Lhx4 *ENSDARG0000003945821
isl1 / P53405 / ISL LIM homeobox 1 / P61371* / P61372* / Insulin enhancer protein ISL-1 *ENSDARG0000000402321
LHX3 / LIM homeobox 3 / Q9UBR4*ENSDARG0000000380320
si:ch211-236k19.2 / LHX6* / Q9R1R0* / Q9UPM6* / LIM homeobox 6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000005216520
lhx8b / LIM homeobox 8b / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000004214519
isl1l / islet1, likeENSDARG0000002105518
si:dkey-90l8.3ENSDARG0000010367615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007634 optokinetic behavior IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021554 optic nerve development IMP
 biological_processGO:0021794 thalamus development IGI
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0071632 optomotor response IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens increased distance retinal pigmented epithelium , abnormal
lens increased distance iridophore , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure aplastic , abnormal
Show

 ZFA:0000107 eye eye movement quality , abnormal
eye degree of pigmentation , abnormal
eye neoplastic , abnormal
eye neoplasm protruding , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium dislocated lens , abnormal
retinal pigmented epithelium organization quality , abnormal
retinal pigmented epithelium spatial pattern , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000418 pretectum pretectum cell mislocalised , abnormal
Show

 ZFA:0000509 epithalamus epithalamus increased size , abnormal
Show

 ZFA:0000556 optic chiasm optic chiasm aplastic , abnormal
optic chiasm absent , abnormal
Show

 ZFA:0000653 dorsal thalamus dorsal thalamus GABAergic neuron mislocalised posteriorly , abnormal
dorsal thalamus cellular quality , abnormal
dorsal thalamus cell mislocalised , abnormal
dorsal thalamus fused with pretectum , abnormal
dorsal thalamus CNS neuron (sensu Vertebrata) poorly differentiated , abnormal
Show

 ZFA:0001094 whole organism whole organism quality , abnormal
whole organism balance , abnormal
whole organism movement behavioral quality , abnormal
whole organism increased pigmentation , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon ipsilateral to brain ipsilateral region, abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
retinal ganglion cell axon displaced to diencephalon , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr