ENSDARG00000004023


Danio rerio

Features
Gene ID: ENSDARG00000004023
  
Biological name :isl1
  
Synonyms : isl1 / ISL LIM homeobox 1 / P53405
  
Possible biological names infered from orthology : Insulin enhancer protein ISL-1 / P61371 / P61372
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 40728613
Gene end: 40734045
  
Corresponding Affymetrix probe sets: Dr.12208.1.S1_s_at (Zebrafish Array)   Dr.279.1.S1_at (Zebrafish Array)   NM_130962_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000012903
NCBI entrez gene - 30147     See in Manteia.
RefSeq - XM_021475997
RefSeq - NM_130962
RefSeq - XM_005165264
RefSeq Peptide - NP_571037
swissprot - P53405
ZFIN ID - ZDB-GENE-980526-112
Ensembl - ENSDARG00000004023
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ISL1ENSGALG00000014884Gallus gallus
 ISL1ENSG00000016082Homo sapiens
 Isl1ENSMUSG00000042258Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
isl2a / P53406 / ISL LIM homeobox 2a / ISL2* / Q96A47* / ISL LIM homeobox 2*ENSDARG0000000397177
isl2b / P53407 / ISL LIM homeobox 2b / ISL2* / Q9CXV0* / Q96A47* / ISL LIM homeobox 2* / Insulin enhancer protein ISL-2 *ENSDARG0000005349975
isl1l / islet1, likeENSDARG0000002105548
lmx1al / LIM homeobox transcription factor 1, alpha-likeENSDARG0000007791530
lmx1ba / LIM homeobox transcription factor 1, beta a / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000010481529
lmx1a / LIM homeobox transcription factor 1, alpha / Q8TE12* / Q9JKU8*ENSDARG0000002035429
lmx1bb / LIM homeobox transcription factor 1, beta b / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000006836528
lhx5 / P52889 / LIM homeobox 5 / Q9H2C1* / P61375* / LIM homeobox protein 5*ENSDARG0000005793628
lhx1a / Q90476 / LIM homeobox 1a / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000001401828
lhx4 / LIM homeobox 4 / P53776* / Q969G2* / LIM/homeobox protein Lhx4 *ENSDARG0000003945828
LHX3 / LIM homeobox 3 / Q9UBR4*ENSDARG0000000380327
lhx1b / LIM homeobox 1b / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000000794427
lhx8a / LIM homeobox 8a / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000000233026
lhx2b / LIM homeobox 2bENSDARG0000003122226
lhx9 / Q1LWV4 / LIM homeobox 9 / Q9WUH2* / Q9NQ69* / LIM/homeobox protein Lhx9 *ENSDARG0000005697926
lhx6 / LIM homeobox 6 / Q9R1R0* / Q9UPM6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000000689626
si:ch211-236k19.2 / LHX6* / Q9R1R0* / Q9UPM6* / LIM homeobox 6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000005216523
lhx8b / LIM homeobox 8b / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000004214523
lhx2a / LIM homeobox 2aENSDARG0000003796422
lmo4a / LIM domain only 4aENSDARG0000001385316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003322 pancreatic A cell development IMP
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0003324 pancreatic D cell development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021527 spinal cord association neuron differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0048936 peripheral nervous system neuron axonogenesis IMP
 biological_processGO:0055011 atrial cardiac muscle cell differentiation IMP
 biological_processGO:0097154 GABAergic neuron differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation pericardium , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus neuron decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart decreased functionality , abnormal
heart edematous , abnormal
Show

 ZFA:0000200 dorsal root ganglion dorsal root ganglion decreased amount , abnormal
dorsal root ganglion neuron projection morphology , abnormal
Show

 ZFA:0000471 atrium atrium cardiac muscle cell decreased amount , abnormal
Show

 ZFA:0000778 spinal cord interneuron spinal cord interneuron decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism immobile , abnormal
whole organism dead , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas lacks parts or has fewer parts of type insulin secreting cell , abnormal
endocrine pancreas lacks parts or has fewer parts of type glucagon secreting cell , abnormal
endocrine pancreas lacks parts or has fewer parts of type somatostatin secreting cell , abnormal
Show

 ZFA:0001370 posterior pancreatic bud posterior pancreatic bud lacks parts or has fewer parts of type insulin secreting cell , abnormal
posterior pancreatic bud lacks parts or has fewer parts of type somatostatin secreting cell , abnormal
Show

 ZFA:0005177 VeLD VeLD increased amount , abnormal
Show

 ZFA:0005179 MiP motor neuron MiP motor neuron axon absent , abnormal
Show

 ZFA:0005240 Kolmer-Agduhr neuron Kolmer-Agduhr neuron increased amount , abnormal
Show

 ZFA:0005437 pectoral fin motor nerve pectoral fin motor nerve axon decreased amount , abnormal
Show

 ZFA:0009019 neuronal stem cell neuronal stem cell decreased amount , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon decreased amount , abnormal
motor neuron axon mislocalised posteriorly , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron axon decreased amount , abnormal
Rohon-Beard neuron decreased amount , abnormal
Rohon-Beard neuron neuronal action potential process quality , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron neuron projection morphology , abnormal
CaP motoneuron neuron projection displaced , abnormal
CaP motoneuron neuronal action potential process quality , abnormal
CaP motoneuron membrane repolarization process quality , abnormal
CaP motoneuron axon absent , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron decreased amount , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron decreased amount , abnormal
secondary motor neuron axon disorganized , abnormal
secondary motor neuron axon decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr