ENSGALG00000014884


Gallus gallus

Features
Gene ID: ENSGALG00000014884
  
Biological name :ISL1
  
Synonyms : Insulin gene enhancer protein ISL-1 / ISL1 / P50211
  
Possible biological names infered from orthology : Insulin enhancer protein ISL-1 / ISL LIM homeobox 1 / P61371 / P61372
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 15144133
Gene end: 15155530
  
Corresponding Affymetrix probe sets: Gga.1507.1.S1_at (Chicken Array)   Gga.1507.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000038117
Ensembl peptide - ENSGALP00000043151
NCBI entrez gene - 396383     See in Manteia.
RefSeq - XM_015277259
RefSeq - NM_205414
RefSeq - XM_015277257
RefSeq Peptide - NP_990745
swissprot - P50211
Ensembl - ENSGALG00000014884
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isl1ENSDARG00000004023Danio rerio
 ISL1ENSG00000016082Homo sapiens
 Isl1ENSMUSG00000042258Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ISL2 / ISL LIM homeobox 2 / Q96A47* / Q9CXV0* / Insulin enhancer protein ISL-2 *ENSGALG0000003339156
LHX5 / Gallus gallus LIM homeobox 5 (LHX5), mRNA. / P61375* / Q9H2C1* / LIM homeobox 5* / LIM homeobox protein 5*ENSGALG0000000830330
LMX1A / LIM homeobox transcription factor 1 alpha / Q8TE12* / Q9JKU8*ENSGALG0000000342430
LMX1B / P53413 / LIM/homeobox protein LMX-1.2 / O60663* / LIM homeobox transcription factor 1 beta*ENSGALG0000004058230
LHX9 / LIM/homeobox protein Lhx9 / Q9NQ69* / Q9WUH2* / LIM homeobox 9*ENSGALG0000000222328
LHX3 / LIM/homeobox protein Lhx3 / Q9UBR4* / P50481* / LIM homeobox 3* / LIM homeobox protein 3*ENSGALG0000000392828
LHX1 / LIM/homeobox protein Lhx1 / P48742* / P63006* / LIM homeobox 1*ENSGALG0000000540928
LHX2 / LIM/homeobox protein Lhx2 ENSGALG0000000112427
LHX6 / LIM homeobox 6 / Q9R1R0* / Q9UPM6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSGALG0000000134727
LHX8 / LIM/homeobox protein Lhx8 / O35652* / Q68G74* / LIM homeobox 8*ENSGALG0000001136926
LHX4 / LIM homeobox 4 / P53776* / Q969G2* / LIM/homeobox protein Lhx4 *ENSGALG0000003658726
LMO4 / LIM domain only 4 / P61968* / P61969* / LIM domain transcription factor LMO4 *ENSGALG0000000625216
ENSGALG0000003567915
LMO3 / LIM domain only 3 / Q8BZL8* / Q8TAP4* / Mus musculus LIM domain only 3 (Lmo3), transcript variant 2, mRNA.*ENSGALG0000003635814
LMO2 / LIM domain only 2 / P25791* / P25801* / Rhombotin-2 *ENSGALG0000002989213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003139 secondary heart field specification IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IEA
 biological_processGO:0003266 regulation of secondary heart field cardioblast proliferation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021524 visceral motor neuron differentiation IEA
 biological_processGO:0021559 trigeminal nerve development IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032730 positive regulation of interleukin-1 alpha production IEA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0048762 mesenchymal cell differentiation IEA
 biological_processGO:0048880 sensory system development IEA
 biological_processGO:0048935 peripheral nervous system neuron development IEA
 biological_processGO:0048936 peripheral nervous system neuron axonogenesis IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060379 cardiac muscle cell myoblast differentiation IEA
 biological_processGO:0060384 innervation IEA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0060913 cardiac cell fate determination IEA
 biological_processGO:0071657 positive regulation of granulocyte colony-stimulating factor production IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1901258 positive regulation of macrophage colony-stimulating factor production IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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