ENSG00000213918


Homo sapiens

Features
Gene ID: ENSG00000213918
  
Biological name :DNASE1
  
Synonyms : deoxyribonuclease 1 / DNASE1 / P24855
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 3611728
Gene end: 3680143
  
Corresponding Affymetrix probe sets: 1557189_at (Human Genome U133 Plus 2.0 Array)   1558546_at (Human Genome U133 Plus 2.0 Array)   210165_at (Human Genome U133 Plus 2.0 Array)   228929_at (Human Genome U133 Plus 2.0 Array)   240144_at (Human Genome U133 Plus 2.0 Array)   241854_at (Human Genome U133 Plus 2.0 Array)   243127_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461745
Ensembl peptide - ENSP00000461527
Ensembl peptide - ENSP00000461725
Ensembl peptide - ENSP00000246949
Ensembl peptide - ENSP00000385905
Ensembl peptide - ENSP00000458467
Ensembl peptide - ENSP00000458959
Ensembl peptide - ENSP00000459507
Ensembl peptide - ENSP00000459850
Ensembl peptide - ENSP00000461129
Ensembl peptide - ENSP00000461153
NCBI entrez gene - 1773     See in Manteia.
OMIM - 125505
RefSeq - XM_017023007
RefSeq - XM_017022996
RefSeq - XM_017022997
RefSeq - XM_017022998
RefSeq - XM_017022999
RefSeq - XM_017023000
RefSeq - XM_017023001
RefSeq - XM_017023002
RefSeq - XM_017023003
RefSeq - XM_017023004
RefSeq - XM_017023005
RefSeq - NM_005223
RefSeq - XM_005255148
RefSeq - XM_006720854
RefSeq - XM_011522393
RefSeq - XM_017022992
RefSeq - XM_017022993
RefSeq - XM_017022994
RefSeq - XM_017022995
RefSeq Peptide - NP_005214
RefSeq Peptide - NP_001338754
swissprot - I3L4B8
swissprot - I3L4C7
swissprot - I3L4U3
swissprot - I3L530
swissprot - I3L0Z9
swissprot - I3L1N2
swissprot - P24855
swissprot - I3L298
Ensembl - ENSG00000213918
  
Related genetic diseases (OMIM): 152700 - {Systemic lupus erythematosus, susceptibility to}, 152700
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnase1ENSDARG00000012539Danio rerio
 Dnase1ENSMUSG00000005980Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92874 / DNASE1L2 / deoxyribonuclease 1 like 2ENSG0000016796854
Q13609 / DNASE1L3 / deoxyribonuclease 1 like 3ENSG0000016368744
P49184 / DNASE1L1 / deoxyribonuclease 1 like 1ENSG0000001356337


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR016202  Deoxyribonuclease I
 IPR018057  Deoxyribonuclease I, active site
 IPR033125  Deoxyribonuclease I, conservied site
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000737 DNA catabolic process, endonucleolytic ISS
 biological_processGO:0002283 neutrophil activation involved in immune response ISS
 biological_processGO:0002673 regulation of acute inflammatory response ISS
 biological_processGO:0006308 DNA catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0070948 regulation of neutrophil mediated cytotoxicity ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004530 deoxyribonuclease I activity IEA
 molecular_functionGO:0004536 deoxyribonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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