ENSG00000249139


Homo sapiens

Features
Gene ID: ENSG00000249139
  
Biological name :EPPIN-WFDC6
  
Synonyms : EPPIN-WFDC6 / EPPIN-WFDC6 readthrough / O95925
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.12
Gene start: 45536986
Gene end: 45547426
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000424176
NCBI entrez gene - 100526773     See in Manteia.
RefSeq - NM_001198986
RefSeq Peptide - NP_001185915
swissprot - O95925
Ensembl - ENSG00000249139
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EppinENSMUSG00000017733Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPPIN / O95925 / epididymal peptidase inhibitorENSG0000010144873
WFDC8 / Q8IUA0 / WAP four-disulfide core domain 8ENSG0000015890131
WFDC6 / Q9BQY6 / WAP four-disulfide core domain 6ENSG0000024354323


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008197  WAP-type "four-disulfide core" domain
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR036645  Elafin-like superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0090281 negative regulation of calcium ion import IMP
 biological_processGO:1901318 negative regulation of flagellated sperm motility IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0097524 sperm plasma membrane TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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