ENSGALG00000006695


Gallus gallus

Features
Gene ID: ENSGALG00000006695
  
Biological name :BCR
  
Synonyms : BCR / BCR, RhoGEF and GTPase activating protein
  
Possible biological names infered from orthology : Breakpoint cluster region protein / P11274 / Q6PAJ1
  
Species: Gallus gallus
  
Chr. number: 15
Strand: -1
Band:
Gene start: 8625525
Gene end: 8717899
  
Corresponding Affymetrix probe sets: Gga.17927.1.A1_at (Chicken Array)   GgaAffx.22022.1.S1_at (Chicken Array)   GgaAffx.22022.2.S1_at (Chicken Array)   GgaAffx.22022.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010805
NCBI entrez gene - 416952     See in Manteia.
RefSeq - XM_015275441
RefSeq - XM_415244
swissprot - E1C0M5
Ensembl - ENSGALG00000006695
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcrENSDARG00000079286Danio rerio
 si:dkey-91m11.5ENSDARG00000042329Danio rerio
 BCRENSG00000186716Homo sapiens
 BcrENSMUSG00000009681Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABR / active BCR-related / Q12979* / Q5SSL4* / active BCR-related gene*ENSGALG0000000436443
ARHGAP21 / Rho GTPase activating protein 21 / Q5T5U3*ENSGALG0000000772114
ARHGAP12 / Rho GTPase activating protein 12 / Q8C0D4* / Q8IWW6*ENSGALG0000000725412
Q5ZMM3 / ARHGAP15 / Rho GTPase-activating protein 15 / Q53QZ3* / Q811M1*ENSGALG000000124219
SYDE2 / synapse defective Rho GTPase homolog 2 / Q5VT97*ENSGALG000000387769
CHN1 / N-chimaerin / P15882* / Q91V57* / chimerin 1*ENSGALG000000092939
ARHGAP23 / Rho GTPase activating protein 23 / Q69ZH9* / Q9P227*ENSGALG000000426288
CHN2* / Q80XD1* / P52757* / AC004593.3* / chimerin 2* / Beta-chimaerin * / beta-chimaerin isoform 3 *ENSGALG000000111648


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000198  Rho GTPase-activating protein domain
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR015123  Bcr-Abl oncoprotein oligomerisation


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002692 negative regulation of cellular extravasation IEA
 biological_processGO:0003014 renal system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043114 regulation of vascular permeability IEA
 biological_processGO:0043314 negative regulation of neutrophil degranulation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051171 regulation of nitrogen compound metabolic process IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060216 definitive hemopoiesis IEA
 biological_processGO:0060268 negative regulation of respiratory burst IEA
 biological_processGO:0060313 negative regulation of blood vessel remodeling IEA
 biological_processGO:0065002 intracellular protein transmembrane transport IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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