ENSMUSG00000009681


Mus musculus

Features
Gene ID: ENSMUSG00000009681
  
Biological name :Bcr
  
Synonyms : Bcr / Breakpoint cluster region protein / Q6PAJ1
  
Possible biological names infered from orthology : BCR, RhoGEF and GTPase activating protein / P11274
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 75060592
Gene end: 75184921
  
Corresponding Affymetrix probe sets: 10363983 (MoGene1.0st)   10364009 (MoGene1.0st)   1427265_at (Mouse Genome 430 2.0 Array)   1452368_at (Mouse Genome 430 2.0 Array)   1455564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151277
Ensembl peptide - ENSMUSP00000151282
Ensembl peptide - ENSMUSP00000126377
NCBI entrez gene - 110279     See in Manteia.
MGI - MGI:88141
RefSeq - XM_006513060
RefSeq - XM_006513061
RefSeq - NM_001081412
RefSeq Peptide - NP_001074881
swissprot - Q6PAJ1
swissprot - A0A1W2P6J3
swissprot - A0A1W2P6I7
Ensembl - ENSMUSG00000009681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcrENSDARG00000079286Danio rerio
 si:dkey-91m11.5ENSDARG00000042329Danio rerio
 BCRENSGALG00000006695Gallus gallus
 BCRENSG00000186716Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abr / Q5SSL4 / active BCR-related gene / Q12979* / active BCR-related*ENSMUSG0000001763146
Arhgap21 / Rho GTPase activating protein 21 / Q5T5U3*ENSMUSG0000003659115
Q8C0D4 / Arhgap12 / Rho GTPase activating protein 12 / Q8IWW6*ENSMUSG0000004122513
Syde2 / synapse defective Rho GTPase homolog 2 / Q5VT97*ENSMUSG0000003686313
A2AB59 / Arhgap27 / Rho GTPase activating protein 27 / Q6ZUM4*ENSMUSG0000003425513
Q69ZH9 / Arhgap23 / Rho GTPase-activating protein 23 / Q9P227*ENSMUSG0000004980712
Syde1 / synapse defective 1, Rho GTPase, homolog 1 (C. elegans) / Q6ZW31* / synapse defective Rho GTPase homolog 1*ENSMUSG000000327149
Q811M1 / Arhgap15 / Rho GTPase activating protein 15 / Q53QZ3*ENSMUSG000000497449
Arhgap9 / Rho GTPase activating protein 9 / Q9BRR9*ENSMUSG000000403459
Chn1 / Q91V57 / N-chimaerin / P15882* / chimerin 1*ENSMUSG000000564869
Chn2 / Q80XD1 / Beta-chimaerin / P52757* / chimerin 2* / AC004593.3* / beta-chimaerin isoform 3 *ENSMUSG000000046338


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000198  Rho GTPase-activating protein domain
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR015123  Bcr-Abl oncoprotein oligomerisation
 IPR035892  C2 domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036481  Bcr-Abl oncoprotein oligomerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002692 negative regulation of cellular extravasation IMP
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007420 brain development IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IGI
 biological_processGO:0030336 negative regulation of cell migration IGI
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0043114 regulation of vascular permeability IMP
 biological_processGO:0043314 negative regulation of neutrophil degranulation IGI
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050766 positive regulation of phagocytosis IGI
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 biological_processGO:0051171 regulation of nitrogen compound metabolic process IMP
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0060268 negative regulation of respiratory burst IMP
 biological_processGO:0060313 negative regulation of blood vessel remodeling IMP
 biological_processGO:0065002 intracellular protein transmembrane transport IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Runx1tm3Dow/Runx1+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Runx1tm3Dow/Runx1+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Runx1tm3Dow/Runx1+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcrtm1(BCR/ABL)Tsr,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003143 enlarged otoliths "increased average size of the crystalline calciferous particles adhering to the otolithic membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003144 reduced number of otoliths "decreased average number of the crystalline calciferous particles adhering to the otolithic membrane" [J:30611, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Runx1tm3Dow/Runx1+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003946 renal necrosis "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Runx1tm3Dow/Runx1+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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