ENSMUSG00000032714


Mus musculus

Features
Gene ID: ENSMUSG00000032714
  
Biological name :Syde1
  
Synonyms : Syde1 / synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
  
Possible biological names infered from orthology : Q6ZW31 / synapse defective Rho GTPase homolog 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 78584503
Gene end: 78591964
  
Corresponding Affymetrix probe sets: 10370510 (MoGene1.0st)   1431798_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043085
NCBI entrez gene - 71709     See in Manteia.
MGI - MGI:1918959
RefSeq - NM_027875
RefSeq - XM_006514148
RefSeq Peptide - NP_082151
swissprot - G3X960
Ensembl - ENSMUSG00000032714
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYDE1ENSG00000105137Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syde2 / synapse defective Rho GTPase homolog 2 / Q5VT97*ENSMUSG0000003686343
Arhgap21 / Rho GTPase activating protein 21 / Q5T5U3*ENSMUSG0000003659119
Q69ZH9 / Arhgap23 / Rho GTPase-activating protein 23 / Q9P227*ENSMUSG0000004980718
Bcr / Q6PAJ1 / Breakpoint cluster region protein / P11274* / BCR, RhoGEF and GTPase activating protein*ENSMUSG0000000968116
A2AB59 / Arhgap27 / Rho GTPase activating protein 27 / Q6ZUM4*ENSMUSG0000003425516
Q8C0D4 / Arhgap12 / Rho GTPase activating protein 12 / Q8IWW6*ENSMUSG0000004122515
Abr / Q5SSL4 / active BCR-related gene / Q12979* / active BCR-related*ENSMUSG0000001763114
Q811M1 / Arhgap15 / Rho GTPase activating protein 15 / Q53QZ3*ENSMUSG0000004974412
Arhgap9 / Rho GTPase activating protein 9 / Q9BRR9*ENSMUSG0000004034512
Chn2 / Q80XD1 / Beta-chimaerin / P52757* / chimerin 2* / AC004593.3* / beta-chimaerin isoform 3 *ENSMUSG0000000463311
Chn1 / Q91V57 / N-chimaerin / P15882* / chimerin 1*ENSMUSG0000005648611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR008936  Rho GTPase activation protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:1901165 positive regulation of trophoblast cell migration IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrdtm1.1Jmag/Gabrd+,Gad2tm2(cre)Zjh/Gad2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrdtm1.1Jmag/Gabrd+,Gad2tm2(cre)Zjh/Gad2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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