ENSMUSG00000004633


Mus musculus

Features
Gene ID: ENSMUSG00000004633
  
Biological name :Chn2
  
Synonyms : Beta-chimaerin / Chn2 / Q80XD1
  
Possible biological names infered from orthology : AC004593.3 / beta-chimaerin isoform 3 / chimerin 2 / P52757
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 54039554
Gene end: 54301810
  
Corresponding Affymetrix probe sets: 10538356 (MoGene1.0st)   1428573_at (Mouse Genome 430 2.0 Array)   1428574_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114476
Ensembl peptide - ENSMUSP00000145507
Ensembl peptide - ENSMUSP00000145314
Ensembl peptide - ENSMUSP00000145231
Ensembl peptide - ENSMUSP00000145072
Ensembl peptide - ENSMUSP00000145008
Ensembl peptide - ENSMUSP00000144983
Ensembl peptide - ENSMUSP00000118990
Ensembl peptide - ENSMUSP00000035908
Ensembl peptide - ENSMUSP00000066078
Ensembl peptide - ENSMUSP00000110043
Ensembl peptide - ENSMUSP00000110044
NCBI entrez gene - 69993     See in Manteia.
MGI - MGI:1917243
RefSeq - XM_006506578
RefSeq - NM_001163640
RefSeq - NM_001311133
RefSeq - NM_001311134
RefSeq - NM_023543
RefSeq Peptide - NP_001157112
RefSeq Peptide - NP_001298062
RefSeq Peptide - NP_001298063
RefSeq Peptide - NP_076032
swissprot - Q3V2R3
swissprot - Q80XD1
swissprot - D3YXQ4
swissprot - A0A0N4SVZ7
swissprot - A0A0N4SVT0
swissprot - A0A0N4SVE7
swissprot - A0A0N4SV75
swissprot - A0A0N4SV96
swissprot - H7BXA9
swissprot - A0A0N4SWG3
swissprot - Q3TVA5
Ensembl - ENSMUSG00000004633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chn2ENSDARG00000011845Danio rerio
 ENSGALG00000011164Gallus gallus
 AC004593.3ENSG00000285162Homo sapiens
 CHN2ENSG00000106069Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chn1 / Q91V57 / N-chimaerin / P15882* / chimerin 1*ENSMUSG0000005648671
Arhgap21 / Rho GTPase activating protein 21 / Q5T5U3*ENSMUSG0000003659125
Q8C0D4 / Arhgap12 / Rho GTPase activating protein 12 / Q8IWW6*ENSMUSG0000004122523
A2AB59 / Arhgap27 / Rho GTPase activating protein 27 / Q6ZUM4*ENSMUSG0000003425523
Bcr / Q6PAJ1 / Breakpoint cluster region protein / P11274* / BCR, RhoGEF and GTPase activating protein*ENSMUSG0000000968122
Q69ZH9 / Arhgap23 / Rho GTPase-activating protein 23 / Q9P227*ENSMUSG0000004980721
Abr / Q5SSL4 / active BCR-related gene / Q12979* / active BCR-related*ENSMUSG0000001763119
Syde2 / synapse defective Rho GTPase homolog 2 / Q5VT97*ENSMUSG0000003686319
Arhgap9 / Rho GTPase activating protein 9 / Q9BRR9*ENSMUSG0000004034518
Q811M1 / Arhgap15 / Rho GTPase activating protein 15 / Q53QZ3*ENSMUSG0000004974418
Syde1 / synapse defective 1, Rho GTPase, homolog 1 (C. elegans) / Q6ZW31* / synapse defective Rho GTPase homolog 1*ENSMUSG0000003271417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000980  SH2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein
 IPR017356  Chimaerin
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR035840  Chimaerin, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045202 synapse ISO
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf13tm1Xuzh/Fgf13tm1Xuzh,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Chn2tm2.1Alk/Chn2tm2.1Alk
Genetic Background: B6.Cg-Chn2tm2.1Alk

Allelic Composition: Chn2tm2.1Alk/Chn2+,Nrp2Gt(GST039)Byg/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

 MP:0008960 abnormal axon pruning "defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf13tm1Xuzh/Fgf13tm1Xuzh,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Chn2tm2.1Alk/Chn2tm2.1Alk
Genetic Background: B6.Cg-Chn2tm2.1Alk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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