ENSMUSG00000049744


Mus musculus

Features
Gene ID: ENSMUSG00000049744
  
Biological name :Arhgap15
  
Synonyms : Arhgap15 / Q811M1 / Rho GTPase activating protein 15
  
Possible biological names infered from orthology : Q53QZ3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 43748824
Gene end: 44395953
  
Corresponding Affymetrix probe sets: 10471929 (MoGene1.0st)   1429881_at (Mouse Genome 430 2.0 Array)   1435959_at (Mouse Genome 430 2.0 Array)   1441650_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056461
Ensembl peptide - ENSMUSP00000108441
Ensembl peptide - ENSMUSP00000108443
NCBI entrez gene - 76117     See in Manteia.
MGI - MGI:1923367
RefSeq - XM_006498402
RefSeq - NM_001301831
RefSeq - NM_001301832
RefSeq - NM_153820
RefSeq - XM_006498397
RefSeq - XM_006498398
RefSeq - XM_006498399
RefSeq - XM_006498400
RefSeq Peptide - NP_001288760
RefSeq Peptide - NP_001288761
RefSeq Peptide - NP_722542
swissprot - B1AW40
swissprot - Q811M1
Ensembl - ENSMUSG00000049744
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap15ENSDARG00000062349Danio rerio
 Q5ZMM3ENSGALG00000012421Gallus gallus
 Q53QZ3ENSG00000075884Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C0D4 / Arhgap12 / Rho GTPase activating protein 12 / Q8IWW6*ENSMUSG0000004122543
A2AB59 / Arhgap27 / Rho GTPase activating protein 27 / Q6ZUM4*ENSMUSG0000003425537
Arhgap9 / Rho GTPase activating protein 9 / Q9BRR9*ENSMUSG0000004034535
Q69ZH9 / Arhgap23 / Rho GTPase-activating protein 23 / Q9P227*ENSMUSG0000004980725
Arhgap21 / Rho GTPase activating protein 21 / Q5T5U3*ENSMUSG0000003659125
Abr / Q5SSL4 / active BCR-related gene / Q12979* / active BCR-related*ENSMUSG0000001763123
Bcr / Q6PAJ1 / Breakpoint cluster region protein / P11274* / BCR, RhoGEF and GTPase activating protein*ENSMUSG0000000968122
Syde2 / synapse defective Rho GTPase homolog 2 / Q5VT97*ENSMUSG0000003686321
Syde1 / synapse defective 1, Rho GTPase, homolog 1 (C. elegans) / Q6ZW31* / synapse defective Rho GTPase homolog 1*ENSMUSG0000003271419
Chn1 / Q91V57 / N-chimaerin / P15882* / chimerin 1*ENSMUSG0000005648618
Chn2 / Q80XD1 / Beta-chimaerin / P52757* / chimerin 2* / AC004593.3* / beta-chimaerin isoform 3 *ENSMUSG0000000463317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005096 GTPase activator activity ISO


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
Show

Allelic Composition: Itgb1tm1Efu/Itgb1tm1Efu,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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