ENSMUSG00000041225


Mus musculus

Features
Gene ID: ENSMUSG00000041225
  
Biological name :Arhgap12
  
Synonyms : Arhgap12 / Q8C0D4 / Rho GTPase activating protein 12
  
Possible biological names infered from orthology : Q8IWW6
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 6024427
Gene end: 6136098
  
Corresponding Affymetrix probe sets: 10457250 (MoGene1.0st)   1431052_at (Mouse Genome 430 2.0 Array)   1444463_at (Mouse Genome 430 2.0 Array)   1451525_at (Mouse Genome 430 2.0 Array)   1451526_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138585
Ensembl peptide - ENSMUSP00000138496
Ensembl peptide - ENSMUSP00000138798
Ensembl peptide - ENSMUSP00000054209
Ensembl peptide - ENSMUSP00000076376
Ensembl peptide - ENSMUSP00000138150
Ensembl peptide - ENSMUSP00000138444
Ensembl peptide - ENSMUSP00000138464
NCBI entrez gene - 75415     See in Manteia.
MGI - MGI:1922665
RefSeq - XM_017318002
RefSeq - NM_001039692
RefSeq - NM_029277
RefSeq - XM_006526314
RefSeq - XM_006526315
RefSeq - XM_006526316
RefSeq - XM_011247018
RefSeq - XM_017318001
RefSeq Peptide - NP_001034781
RefSeq Peptide - NP_083553
swissprot - S4R248
swissprot - B2RUJ8
swissprot - S4R2V0
swissprot - A0A0A0MQ95
swissprot - Q8C0D4
swissprot - S4R203
swissprot - S4R1B0
swissprot - S4R221
Ensembl - ENSMUSG00000041225
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap12aENSDARG00000008548Danio rerio
 arhgap12bENSDARG00000026482Danio rerio
 ARHGAP12ENSGALG00000007254Gallus gallus
 Q8IWW6ENSG00000165322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2AB59 / Arhgap27 / Rho GTPase activating protein 27 / Q6ZUM4*ENSMUSG0000003425536
Q811M1 / Arhgap15 / Rho GTPase activating protein 15 / Q53QZ3*ENSMUSG0000004974425
Arhgap21 / Rho GTPase activating protein 21 / Q5T5U3*ENSMUSG0000003659123
Arhgap9 / Rho GTPase activating protein 9 / Q9BRR9*ENSMUSG0000004034521
Q69ZH9 / Arhgap23 / Rho GTPase-activating protein 23 / Q9P227*ENSMUSG0000004980719
Bcr / Q6PAJ1 / Breakpoint cluster region protein / P11274* / BCR, RhoGEF and GTPase activating protein*ENSMUSG0000000968119
Abr / Q5SSL4 / active BCR-related gene / Q12979* / active BCR-related*ENSMUSG0000001763117
Syde2 / synapse defective Rho GTPase homolog 2 / Q5VT97*ENSMUSG0000003686317
Syde1 / synapse defective 1, Rho GTPase, homolog 1 (C. elegans) / Q6ZW31* / synapse defective Rho GTPase homolog 1*ENSMUSG0000003271413
Chn1 / Q91V57 / N-chimaerin / P15882* / chimerin 1*ENSMUSG0000005648613
Chn2 / Q80XD1 / Beta-chimaerin / P52757* / chimerin 2* / AC004593.3* / beta-chimaerin isoform 3 *ENSMUSG0000000463313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001202  WW domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR035491  ARHGAP12, SH3 domain
 IPR036020  WW domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002011 morphogenesis of an epithelial sheet IEA
 biological_processGO:0006911 phagocytosis, engulfment IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051058 negative regulation of small GTPase mediated signal transduction IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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