ENSG00000165322


Homo sapiens

Features
Gene ID: ENSG00000165322
  
Biological name :ARHGAP12
  
Synonyms : ARHGAP12 / Q8IWW6 / Rho GTPase activating protein 12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.22
Gene start: 31805404
Gene end: 31928876
  
Corresponding Affymetrix probe sets: 207606_s_at (Human Genome U133 Plus 2.0 Array)   243216_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398050
Ensembl peptide - ENSP00000364399
Ensembl peptide - ENSP00000379448
Ensembl peptide - ENSP00000310984
Ensembl peptide - ENSP00000345808
Ensembl peptide - ENSP00000364394
NCBI entrez gene - 94134     See in Manteia.
OMIM - 610577
RefSeq - XM_017016954
RefSeq - NM_001270695
RefSeq - NM_001270696
RefSeq - NM_001270697
RefSeq - NM_001270698
RefSeq - NM_001270699
RefSeq - NM_018287
RefSeq - XM_005252644
RefSeq - XM_011519761
RefSeq Peptide - NP_001257626
RefSeq Peptide - NP_001257627
RefSeq Peptide - NP_001257628
RefSeq Peptide - NP_060757
RefSeq Peptide - NP_001257624
RefSeq Peptide - NP_001257625
swissprot - H0Y5D8
swissprot - Q1RLN5
swissprot - Q8IWW6
Ensembl - ENSG00000165322
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap12aENSDARG00000008548Danio rerio
 arhgap12bENSDARG00000026482Danio rerio
 ARHGAP12ENSGALG00000007254Gallus gallus
 Q8C0D4ENSMUSG00000041225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZUM4 / ARHGAP27 / Rho GTPase activating protein 27ENSG0000015931436
Q9BRR9 / ARHGAP9 / Rho GTPase activating protein 9ENSG0000012332928
Q53QZ3 / ARHGAP15 / Rho GTPase activating protein 15ENSG0000007588426
Q5T5U3 / ARHGAP21 / Rho GTPase activating protein 21ENSG0000010786323
Q9P227 / ARHGAP23 / Rho GTPase activating protein 23ENSG0000027583221
BCR / P11274 / BCR, RhoGEF and GTPase activating proteinENSG0000018671619
SYDE2 / Q5VT97 / synapse defective Rho GTPase homolog 2ENSG0000009709617
ABR / Q12979 / active BCR-relatedENSG0000015984216
AC004593.3 / beta-chimaerin isoform 3 ENSG0000028516213
SYDE1 / Q6ZW31 / synapse defective Rho GTPase homolog 1ENSG0000010513713
CHN1 / P15882 / chimerin 1ENSG0000012865613
CHN2 / P52757 / chimerin 2ENSG0000010606913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001202  WW domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR035491  ARHGAP12, SH3 domain
 IPR036020  WW domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002011 morphogenesis of an epithelial sheet IMP
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051058 negative regulation of small GTPase mediated signal transduction IMP
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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