ENSG00000159842


Homo sapiens

Features
Gene ID: ENSG00000159842
  
Biological name :ABR
  
Synonyms : ABR / active BCR-related / Q12979
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.3
Gene start: 1003518
Gene end: 1229021
  
Corresponding Affymetrix probe sets: 212895_s_at (Human Genome U133 Plus 2.0 Array)   214671_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461565
Ensembl peptide - ENSP00000460770
Ensembl peptide - ENSP00000461629
Ensembl peptide - ENSP00000487388
Ensembl peptide - ENSP00000461795
Ensembl peptide - ENSP00000291107
Ensembl peptide - ENSP00000303909
Ensembl peptide - ENSP00000437429
Ensembl peptide - ENSP00000442048
Ensembl peptide - ENSP00000445198
Ensembl peptide - ENSP00000458294
Ensembl peptide - ENSP00000459118
Ensembl peptide - ENSP00000459406
Ensembl peptide - ENSP00000459553
Ensembl peptide - ENSP00000459761
Ensembl peptide - ENSP00000459820
Ensembl peptide - ENSP00000460248
NCBI entrez gene - 29     See in Manteia.
OMIM - 600365
RefSeq - XM_017024543
RefSeq - NM_001092
RefSeq - NM_001159746
RefSeq - NM_001256847
RefSeq - NM_001282149
RefSeq - NM_001322840
RefSeq - NM_001322841
RefSeq - NM_021962
RefSeq - XM_011523810
RefSeq - XM_011523811
RefSeq - XM_011523812
RefSeq - XM_011523813
RefSeq - XM_011523814
RefSeq - XM_011523815
RefSeq - XM_017024539
RefSeq - XM_017024540
RefSeq - XM_017024541
RefSeq - XM_017024542
RefSeq Peptide - NP_001083
RefSeq Peptide - NP_001153218
RefSeq Peptide - NP_001243776
RefSeq Peptide - NP_001269078
RefSeq Peptide - NP_001309769
RefSeq Peptide - NP_001309770
RefSeq Peptide - NP_068781
swissprot - I3L2C0
swissprot - Q12979
swissprot - I3L2P5
swissprot - I3L379
swissprot - I3L3W0
swissprot - I3L4Y1
swissprot - I3NI05
swissprot - I3L2L3
swissprot - A0A0D9SGD7
swissprot - B7Z683
swissprot - A0A1C7CYZ0
swissprot - I3L0R7
swissprot - I3L1U8
swissprot - I3L259
Ensembl - ENSG00000159842
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abrENSDARG00000095180Danio rerio
 ABRENSGALG00000004364Gallus gallus
 AbrENSMUSG00000017631Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCR / P11274 / BCR, RhoGEF and GTPase activating proteinENSG0000018671668
Q8IWW6 / ARHGAP12 / Rho GTPase activating protein 12ENSG0000016532216
Q6ZUM4 / ARHGAP27 / Rho GTPase activating protein 27ENSG0000015931416
Q5T5U3 / ARHGAP21 / Rho GTPase activating protein 21ENSG0000010786315
Q9P227 / ARHGAP23 / Rho GTPase activating protein 23ENSG0000027583215
SYDE2 / Q5VT97 / synapse defective Rho GTPase homolog 2ENSG0000009709614
Q9BRR9 / ARHGAP9 / Rho GTPase activating protein 9ENSG0000012332914
Q53QZ3 / ARHGAP15 / Rho GTPase activating protein 15ENSG0000007588413
SYDE1 / Q6ZW31 / synapse defective Rho GTPase homolog 1ENSG0000010513712
CHN1 / P15882 / chimerin 1ENSG0000012865611
CHN2 / P52757 / chimerin 2ENSG0000010606910
AC004593.3 / beta-chimaerin isoform 3 ENSG0000028516210


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000198  Rho GTPase-activating protein domain
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002692 negative regulation of cellular extravasation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043114 regulation of vascular permeability IEA
 biological_processGO:0043314 negative regulation of neutrophil degranulation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060313 negative regulation of blood vessel remodeling IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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