ENSG00000107863


Homo sapiens

Features
Gene ID: ENSG00000107863
  
Biological name :ARHGAP21
  
Synonyms : ARHGAP21 / Q5T5U3 / Rho GTPase activating protein 21
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p12.1
Gene start: 24583609
Gene end: 24723668
  
Corresponding Affymetrix probe sets: 224764_at (Human Genome U133 Plus 2.0 Array)   241701_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402761
Ensembl peptide - ENSP00000400566
Ensembl peptide - ENSP00000405018
Ensembl peptide - ENSP00000490730
Ensembl peptide - ENSP00000490396
Ensembl peptide - ENSP00000489905
Ensembl peptide - ENSP00000480005
Ensembl peptide - ENSP00000365592
Ensembl peptide - ENSP00000365604
Ensembl peptide - ENSP00000379709
Ensembl peptide - ENSP00000389940
NCBI entrez gene - 57584     See in Manteia.
OMIM - 609870
RefSeq - XM_017016461
RefSeq - NM_020824
RefSeq - XM_005252542
RefSeq - XM_005252544
RefSeq - XM_011519602
RefSeq - XM_011519603
RefSeq - XM_011519604
RefSeq - XM_011519605
RefSeq - XM_011519606
RefSeq - XM_011519607
RefSeq - XM_017016459
RefSeq - XM_017016460
RefSeq Peptide - NP_065875
swissprot - A0A1B0GW11
swissprot - A0A1B0GV73
swissprot - A0A1B0GTZ9
swissprot - F8W9U9
swissprot - H0Y468
swissprot - H0Y5T2
swissprot - A0A087WW76
swissprot - Q5JSD8
swissprot - E7ESW5
swissprot - Q5T5U3
Ensembl - ENSG00000107863
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap21aENSDARG00000104295Danio rerio
 arhgap21bENSDARG00000075673Danio rerio
 ARHGAP21ENSGALG00000007721Gallus gallus
 Arhgap21ENSMUSG00000036591Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9P227 / ARHGAP23 / Rho GTPase activating protein 23ENSG0000027583232
BCR / P11274 / BCR, RhoGEF and GTPase activating proteinENSG0000018671610
Q8IWW6 / ARHGAP12 / Rho GTPase activating protein 12ENSG0000016532210
SYDE2 / Q5VT97 / synapse defective Rho GTPase homolog 2ENSG000000970969
Q6ZUM4 / ARHGAP27 / Rho GTPase activating protein 27ENSG000001593149
Q9BRR9 / ARHGAP9 / Rho GTPase activating protein 9ENSG000001233297
Q53QZ3 / ARHGAP15 / Rho GTPase activating protein 15ENSG000000758847
SYDE1 / Q6ZW31 / synapse defective Rho GTPase homolog 1ENSG000001051377
AC004593.3 / beta-chimaerin isoform 3 ENSG000002851626
ABR / Q12979 / active BCR-relatedENSG000001598426
CHN2 / P52757 / chimerin 2ENSG000001060696
CHN1 / P15882 / chimerin 1ENSG000001286566


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051683 establishment of Golgi localization IDA
 biological_processGO:0051684 maintenance of Golgi location IMP
 biological_processGO:0072384 organelle transport along microtubule IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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