ENSG00000106069


Homo sapiens

Features
Gene ID: ENSG00000106069
  
Biological name :CHN2
  
Synonyms : chimerin 2 / CHN2 / P52757
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p14.3
Gene start: 29146569
Gene end: 29514328
  
Corresponding Affymetrix probe sets: 207486_x_at (Human Genome U133 Plus 2.0 Array)   211419_s_at (Human Genome U133 Plus 2.0 Array)   213385_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396867
Ensembl peptide - ENSP00000394284
Ensembl peptide - ENSP00000398326
Ensembl peptide - ENSP00000486515
Ensembl peptide - ENSP00000441183
Ensembl peptide - ENSP00000438587
Ensembl peptide - ENSP00000409843
Ensembl peptide - ENSP00000406337
Ensembl peptide - ENSP00000222792
Ensembl peptide - ENSP00000386849
Ensembl peptide - ENSP00000386968
Ensembl peptide - ENSP00000387425
NCBI entrez gene - 1124     See in Manteia.
OMIM - 602857
RefSeq - NM_001293079
RefSeq - NM_001039936
RefSeq - NM_001293070
RefSeq - NM_001293071
RefSeq - NM_001293072
RefSeq - NM_001293073
RefSeq - NM_001293075
RefSeq - NM_001293076
RefSeq - NM_001293077
RefSeq - NM_001293078
RefSeq - NM_001293080
RefSeq - NM_001293081
RefSeq - NM_004067
RefSeq - XM_011515107
RefSeq - XM_017011722
RefSeq Peptide - NP_001280007
RefSeq Peptide - NP_001280008
RefSeq Peptide - NP_001280009
RefSeq Peptide - NP_001280010
RefSeq Peptide - NP_004058
RefSeq Peptide - NP_001035025
RefSeq Peptide - NP_001279999
RefSeq Peptide - NP_001280000
RefSeq Peptide - NP_001280001
RefSeq Peptide - NP_001280002
RefSeq Peptide - NP_001280004
RefSeq Peptide - NP_001280005
RefSeq Peptide - NP_001280006
swissprot - B3VCF4
swissprot - B3VCF5
swissprot - H0YG02
swissprot - P52757
swissprot - H7C0V3
swissprot - H7C138
swissprot - C9JQ94
swissprot - B8ZZU1
swissprot - B3VCG5
swissprot - B3VCF6
Ensembl - ENSG00000106069
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chn2ENSDARG00000011845Danio rerio
 ENSGALG00000011164Gallus gallus
 Chn2ENSMUSG00000004633Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC004593.3 / beta-chimaerin isoform 3 ENSG0000028516298
CHN1 / P15882 / chimerin 1ENSG0000012865672
Q5T5U3 / ARHGAP21 / Rho GTPase activating protein 21ENSG0000010786326
Q9P227 / ARHGAP23 / Rho GTPase activating protein 23ENSG0000027583225
Q8IWW6 / ARHGAP12 / Rho GTPase activating protein 12ENSG0000016532224
BCR / P11274 / BCR, RhoGEF and GTPase activating proteinENSG0000018671622
Q6ZUM4 / ARHGAP27 / Rho GTPase activating protein 27ENSG0000015931422
Q9BRR9 / ARHGAP9 / Rho GTPase activating protein 9ENSG0000012332922
SYDE2 / Q5VT97 / synapse defective Rho GTPase homolog 2ENSG0000009709620
Q53QZ3 / ARHGAP15 / Rho GTPase activating protein 15ENSG0000007588418
ABR / Q12979 / active BCR-relatedENSG0000015984218
SYDE1 / Q6ZW31 / synapse defective Rho GTPase homolog 1ENSG0000010513717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000980  SH2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein
 IPR017356  Chimaerin
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR035840  Chimaerin, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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