ENSG00000159314


Homo sapiens

Features
Gene ID: ENSG00000159314
  
Biological name :ARHGAP27
  
Synonyms : ARHGAP27 / Q6ZUM4 / Rho GTPase activating protein 27
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 45393902
Gene end: 45434421
  
Corresponding Affymetrix probe sets: 1554594_at (Human Genome U133 Plus 2.0 Array)   225618_at (Human Genome U133 Plus 2.0 Array)   227057_at (Human Genome U133 Plus 2.0 Array)   229424_s_at (Human Genome U133 Plus 2.0 Array)   243536_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431591
Ensembl peptide - ENSP00000403323
Ensembl peptide - ENSP00000431722
Ensembl peptide - ENSP00000437100
Ensembl peptide - ENSP00000436137
Ensembl peptide - ENSP00000433942
Ensembl peptide - ENSP00000432762
Ensembl peptide - ENSP00000290470
Ensembl peptide - ENSP00000366121
NCBI entrez gene - 201176     See in Manteia.
OMIM - 610591
RefSeq - XM_017024312
RefSeq - XM_006721745
RefSeq - XM_006721747
RefSeq - XM_011524468
RefSeq - XM_011524469
RefSeq - XM_011524470
RefSeq - XM_011524471
RefSeq - XM_011524472
RefSeq - XM_011524474
RefSeq - XM_017024311
RefSeq - NM_001282290
RefSeq - NM_174919
RefSeq - NM_199282
RefSeq - XM_005257128
RefSeq Peptide - NP_777579
RefSeq Peptide - NP_954976
RefSeq Peptide - NP_001269219
swissprot - E9PIR1
swissprot - E9PNX6
swissprot - Q6ZUM4
swissprot - A0A0C4DGE6
swissprot - E9PNT2
swissprot - E9PK18
Ensembl - ENSG00000159314
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap27ENSDARG00000104255Danio rerio
 arhgap27lENSDARG00000061798Danio rerio
 A2AB59ENSMUSG00000034255Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IWW6 / ARHGAP12 / Rho GTPase activating protein 12ENSG0000016532235
Q9BRR9 / ARHGAP9 / Rho GTPase activating protein 9ENSG0000012332926
Q53QZ3 / ARHGAP15 / Rho GTPase activating protein 15ENSG0000007588422
Q5T5U3 / ARHGAP21 / Rho GTPase activating protein 21ENSG0000010786321
Q9P227 / ARHGAP23 / Rho GTPase activating protein 23ENSG0000027583219
BCR / P11274 / BCR, RhoGEF and GTPase activating proteinENSG0000018671618
SYDE2 / Q5VT97 / synapse defective Rho GTPase homolog 2ENSG0000009709617
ABR / Q12979 / active BCR-relatedENSG0000015984216
SYDE1 / Q6ZW31 / synapse defective Rho GTPase homolog 1ENSG0000010513713
CHN2 / P52757 / chimerin 2ENSG0000010606912
CHN1 / P15882 / chimerin 1ENSG0000012865612
AC004593.3 / beta-chimaerin isoform 3 ENSG0000028516212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001202  WW domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR011993  PH-like domain superfamily
 IPR036020  WW domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005096 GTPase activator activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding ISS


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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