ENSGALG00000016524


Gallus gallus

Features
Gene ID: ENSGALG00000016524
  
Biological name :CAD
  
Synonyms : CAD / carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  
Possible biological names infered from orthology : B2RQC6 / CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase / P27708
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 104970733
Gene end: 104980694
  
Corresponding Affymetrix probe sets: Gga.5992.1.S1_s_at (Chicken Array)   Gga.7514.2.S1_at (Chicken Array)   GgaAffx.24991.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000026615
NCBI entrez gene - 428659     See in Manteia.
RefSeq - XM_015284989
RefSeq - XM_015284990
swissprot - E1BTX8
Ensembl - ENSGALG00000016524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cadENSDARG00000041895Danio rerio
 CADENSG00000084774Homo sapiens
 CadENSMUSG00000013629Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CPS1 / carbamoyl-phosphate synthase / P31327* / Q8C196* / carbamoyl-phosphate synthase 1* / Carbamoyl-phosphate synthase [ammonia], mitochondrial *ENSGALG0000000294436


Protein motifs (from Interpro)
Interpro ID Name
 IPR002195  Dihydroorotase, conserved site
 IPR002474  Carbamoyl-phosphate synthase small subunit, N-terminal domain
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005480  Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
 IPR005483  Carbamoyl-phosphate synthase large subunit, CPSase domain
 IPR006274  Carbamoyl-phosphate synthase, small subunit
 IPR006275  Carbamoyl-phosphate synthase, large subunit
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011607  Methylglyoxal synthase-like domain
 IPR011761  ATP-grasp fold
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR017926  Glutamine amidotransferase
 IPR029062  Class I glutamine amidotransferase-like
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle IBA
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IBA
 biological_processGO:0006526 arginine biosynthetic process IBA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004070 aspartate carbamoyltransferase activity IBA
 molecular_functionGO:0004087 carbamoyl-phosphate synthase (ammonia) activity IBA
 molecular_functionGO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
 molecular_functionGO:0004151 dihydroorotase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pyrimidine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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