ENSDARG00000041895


Danio rerio

Features
Gene ID: ENSDARG00000041895
  
Biological name :cad
  
Synonyms : cad / carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  
Possible biological names infered from orthology : B2RQC6 / CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase / P27708
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 38788319
Gene end: 38827623
  
Corresponding Affymetrix probe sets: Dr.2668.1.S1_at (Zebrafish Array)   Dr.2668.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000106816
Ensembl peptide - ENSDARP00000127377
NCBI entrez gene - 266992     See in Manteia.
RefSeq - NM_001308825
RefSeq Peptide - NP_001295754
swissprot - F1Q9V4
swissprot - U3JAV8
ZFIN ID - ZDB-GENE-021030-4
Ensembl - ENSDARG00000041895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CADENSGALG00000016524Gallus gallus
 CADENSG00000084774Homo sapiens
 CadENSMUSG00000013629Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cps1 / carbamoyl-phosphate synthase 1, mitochondrial / P31327* / Q8C196* / carbamoyl-phosphate synthase 1* / Carbamoyl-phosphate synthase [ammonia], mitochondrial *ENSDARG0000002002836


Protein motifs (from Interpro)
Interpro ID Name
 IPR002082  Aspartate carbamoyltransferase
 IPR002195  Dihydroorotase, conserved site
 IPR002474  Carbamoyl-phosphate synthase small subunit, N-terminal domain
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005480  Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
 IPR005483  Carbamoyl-phosphate synthase large subunit, CPSase domain
 IPR006130  Aspartate/ornithine carbamoyltransferase
 IPR006131  Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
 IPR006132  Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
 IPR006274  Carbamoyl-phosphate synthase, small subunit
 IPR006275  Carbamoyl-phosphate synthase, large subunit
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011607  Methylglyoxal synthase-like domain
 IPR011761  ATP-grasp fold
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR017926  Glutamine amidotransferase
 IPR029062  Class I glutamine amidotransferase-like
 IPR032466  Metal-dependent hydrolase
 IPR035686  Carbamoyl-phosphate synthase small subunit, GATase1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IMP
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0021610 facial nerve morphogenesis IMP
 biological_processGO:0021615 glossopharyngeal nerve morphogenesis IMP
 biological_processGO:0021636 trigeminal nerve morphogenesis IMP
 biological_processGO:0021644 vagus nerve morphogenesis IMP
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IGI
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IGI
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004070 aspartate carbamoyltransferase activity IEA
 molecular_functionGO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016743 carboxyl- or carbamoyltransferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pyrimidine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain mitotic cell cycle decreased process quality , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk quality , abnormal
yolk circular , abnormal
Show

 ZFA:0000100 cerebellum cerebellum structure , abnormal
cerebellum decreased size , abnormal
Show

 ZFA:0000106 extension extension decreased thickness , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye cell death increased process quality , abnormal
Show

 ZFA:0000109 forebrain forebrain cell death increased process quality , abnormal
Show

 ZFA:0000112 gut gut quality , abnormal
gut hypoplastic , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000123 liver liver quality , abnormal
liver hypoplastic , abnormal
Show

 ZFA:0000128 midbrain midbrain posterior margin increased width , abnormal
midbrain cell death increased process quality , abnormal
Show

 ZFA:0000445 optic tectum optic tectum central region proliferative , abnormal
optic tectum cell proliferation in midbrain increased occurrence , abnormal
optic tectum regulation of neurogenesis process quality , abnormal
optic tectum apoptotic process increased occurrence , abnormal
optic tectum structure , abnormal
optic tectum decreased size , abnormal
Show

 ZFA:0001061 intersegmental artery intersegmental artery increased branchiness , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage shortened , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch atrophied , abnormal
Show

 ZFA:0001291 facial ganglion facial ganglion decreased size , abnormal
facial ganglion axon malformed , abnormal
Show

 ZFA:0001301 glossopharyngeal ganglion glossopharyngeal ganglion decreased size , abnormal
glossopharyngeal ganglion lacks parts or has fewer parts of type glossopharyngeal ganglion axon, abnormal
glossopharyngeal ganglion axon malformed , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage deformed , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
Show

 ZFA:0001555 epibranchial ganglion epibranchial ganglion axon morphology , abnormal
epibranchial ganglion axon development process quality , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
Show

 ZFA:0007067 vagal ganglion vagal ganglion decreased size , abnormal
vagal ganglion axon malformed , abnormal
vagal ganglion fasciculation of sensory neuron axon decreased process quality , abnormal
Show

 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell increased amount , abnormal
Show

 ZFA:0009395 vascular lymphangioblast vascular lymphangioblast increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000041895 cad / carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase / B2RQC6* / P27708* / CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyl...  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr